Exhibit 99.2

 

SS Simmons first national corporation Nasdaq: SFNC 3rd Quarter 2024 Earnings Presentation Contents 3 Company Profile 4 3Q24 Financial Highlights 11 Deposits, Securities, Liquidity, Interest Rate Sensitivity and Capital 18 Loan Portfolio 24 Credit Quality 28 Appendix Simmons bank

2 Forward-Looking Statements and Non-GAAP Financial Measures Forward-Looking Statements. Certain statements by Simmons First National Corporation (the “Company”, which where appropriate includes the Company’s wholly-owned banking subsidiary, Simmons Bank) contained in this presentation may not be based on historical facts and should be considered “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements may be identified by reference to a future period(s) or by the use of forward-looking terminology, such as “anticipate,” “believe,” “continue,” “estimate,” “expect,” “foresee,“ “indicate,” “plan,” “potential,” “project,” “target,” “may,” “might,” “will,” “would,” “could,“ “should,” “likely” or “intend,” future or conditional verb tenses, and variations or negatives of such terms or by similar expressions. These forward-looking statements include, without limitation, statements relating to the Company’s future growth; business strategies; product development; revenue; expenses (including interest expense and non-interest expenses); assets; loan demand (including loan growth, loan capacity, and other lending activity); deposit levels; asset quality; profitability; earnings; critical accounting policies; accretion; net interest margin; noninterest income; the Company’s common stock repurchase program; adequacy of the allowance for credit losses; income tax deductions; credit quality; level of credit losses from lending commitments; net interest revenue; interest rate sensitivity (including, among other things, the potential impact of rising rates); loan loss experience; liquidity; capital resources; future economic conditions and market risk; interest rates; the expected expenses and cost savings associated with branch closures; the Company’s ability to recruit and retain key employees; increases in, and cash flows associated with, the Company’s securities portfolio; legal and regulatory limitations and compliance and competition; anticipated loan principal reductions; plans for investments in and cash flows from securities; the estimated annual impact of securities sales; estimated earn back periods; projections regarding loan repricing, securities investments and maturities thereof; estimates of future swap income set forth on slide 8; the interest rate sensitivity estimates and projections noted on slide 15; and dividends. Readers are cautioned not to place undue reliance on the forward-looking statements contained in this presentation in that actual results could differ materially from those indicated in or implied by such forward-looking statements due to a variety of factors. These factors include, but are not limited to, changes in the Company’s operating or expansion strategy; the availability of and costs associated with obtaining adequate and timely sources of liquidity; the ability to maintain credit quality; changes in general market and economic conditions; increased unemployment; labor shortages; possible adverse rulings, judgments, settlements and other outcomes of pending or future litigation; the ability of the Company to collect amounts due under loan agreements; changes in consumer preferences and loan demand; the effectiveness of the Company’s interest rate risk management strategies; laws and regulations affecting financial institutions in general or relating to taxes; the effect of pending or future legislation; changes in governmental administrations; the ability of the Company to repurchase its common stock on favorable terms; the ability of the Company to successfully manage and implement its acquisition strategy and integrate acquired institutions; difficulties and delays in integrating an acquired business or fully realizing cost savings and other benefits of mergers and acquisitions; changes in interest rates, deposit flows, real estate values, and capital markets; increased inflation; customer acceptance of the Company’s products and services; changes or disruptions in technology and IT systems (including cyber threats, attacks and events); changes in accounting principles relating to loan loss recognition (current expected credit losses, or CECL); the benefits associated with the Company’s early retirement program; political crises, war, and other military conflicts (including the ongoing military conflicts between Russia and Ukraine and between Israel and Hamas) or other major events, or the prospect of these events; increased competition in the markets in which the Company operates and from non-bank financial institutions; changes in governmental policies; loss of key employees; the soundness of other financial institutions and any indirect exposure related to the closings of other financial institutions and their impact on the broader market through other customers, suppliers and partners, or that the conditions which resulted in the liquidity concerns experienced by closed financial institutions may also adversely impact, directly or indirectly, other financial institutions and market participants with which the Company has commercial or deposit relationships; increased delinquency and foreclosure rates on commercial real estate loans; and other risk factors. Other relevant risk factors may be detailed from time to time in the Company’s press releases and filings with the U.S. Securities and Exchange Commission, including, without limitation, the Company’s Form 10-K for the year ended December 31, 2023. In addition, there can be no guarantee that the board of directors (“Board”) of the Company will approve a quarterly dividend in future quarters, and the timing, payment, and amount of future dividends (if any) is subject to, among other things, the discretion of the Board and may differ significantly from past dividends. Any forward-looking statement speaks only as of the date of this presentation, and the Company undertakes no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date of this presentation. Annualized, pro forma, projected and estimated numbers are used for illustrative purpose only, are not forecasts and may not reflect actual results. Non-GAAP Financial Measures. This presentation contains financial information determined by methods other than in accordance with U.S. generally accepted accounting principles (“GAAP”). The Company’s management uses these non-GAAP financial measures in their analysis of the Company’s performance and capital adequacy. These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax-exempt, as well as exclude from net income (including on a per share diluted basis), pre-tax, pre-provision earnings, net charge-offs, income available to common shareholders, non-interest income, and non-interest expense certain income and expense items attributable to, for example, merger activity (primarily including merger-related expenses), gains and/or losses on sale of branches, net branch right-sizing initiatives, FDIC special assessment charges and gain/loss on the sale of AFS investment securities. The Company has updated its calculation of certain non-GAAP financial measures to exclude the impact of gains or losses on the sale of AFS investment securities in light of the impact of the Company’s strategic AFS investment securities transactions during the fourth quarter of 2023, and has presented past periods on a comparable basis. In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets, and presents certain other figures to include the effect that accumulated other comprehensive income could have on the Company’s capital levels . The Company further presents certain figures that are exclusive of the impact of deposits and/or loans acquired through acquisitions, mortgage warehouse loans, and/or energy loans, or gains and/or losses on the sale of securities. The Company’s management believes that these non-GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, present the Company’s capital inclusive of the potential impact of AOCI (primarily comprised of unrealized losses on securities), as well as normalize for tax effects and certain other effects. Management, therefore, believes presentations of these non-GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non-GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods. These non-GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non-GAAP performance measures that may be presented by other companies. Where non-GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the appendix to this presentation.

Simmons First National Corporation A Mid-South based financial holding company serving our customers and the communities where we work and live since 1903 115 CONSECUTIVE YEARS PAYING DIVIDENDS3 121 YEARS OF SERVICE 234 FINANCIAL CENTERS ACROSS SIX STATES Figures presented on this slide are as of September 30, 2024, unless otherwise noted 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 2 Based on October 8, 2024, closing stock price of $21.27 and projected annualized dividend rate of $0.84 per share 3 The future payment of dividends is not guaranteed and is subject to various factors, including approval by the Company’s board of directors Company Overview $27.3 BILLION TOTAL ASSETS $21.9 BILLION TOTAL DEPOSITS 115 CONSECUTIVE YEARS PAYING DIVIDENDS3 $8.7 BILLION ASSETS UNDER MANAGEMENT/ ADMINISTRATION $17.3 BILLION TOTAL LOANS 121 YEARS OF SERVICE 234 FINANCIAL CENTERS ACROSS SIX STATES 14.3% TOTAL RBC RATIO 8.2% TCE RATIO1 3.9% DIVIDEND YIELD2 79% LOAN TO DEPOSIT RATIO 1.35% ACL TO TOTAL LOANS 229% NPL COVERAGE RATIO Forbes 2024 best-in-state banks powered by statista Best companies to work for u.s.news a world report in the south 2024-2025 Forbes 2024 america’s best-in-state employers powered by statista

3Q24 Financial Highlights Simmons first national corporation Simmons bank 4

5 PPNR2 $37.6M $66.4M Revenue $174.8M $203.2M EPS (diluted) $0.20 $0.37 Net income $24.7M $46.0M 5 3Q24 Highlights 1 Non-GAAP measures that management believes aid in the discussion of results. See Appendix for Non-GAAP reconciliation 2 All pre-provision net revenue (PPNR) figures set forth in this row are Non-GAAP measures. See footnote 1 for more information 3 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios. See pages 20, 24, 26 and 27 for more information â–ª Third quarter results Reported Adjusted1 — Average loans up 2% on a linked quarter annualized basis — NIM at 2.74%, up 5 bps vs 2Q24; 3 bps benefit from sale of bonds — Cost of deposits flat vs 2Q24; deposit costs peaked in June — Credit quality remains sound • Provision for credit losses on loans exceeded NCOs by $2.8 million • 9 bps of net charge-offs associated with run-off portfolio3 • ACL ratio at 1.35% â–ª Balance Sheet Optimization — Capitalized on market conditions with the targeted sale of $252 million of AFS securities at a $21.0 million after-tax loss • Yield on AFS securities sold was 1.29% • Proceeds used to paydown wholesale funding â–ª Completed annual branch network review — Identified 13 branches that will be closed during 4Q24 • Estimated one-time expenses of ~$5.4 million • Estimated annual net cost savings of ~$3.0 million, a portion to be reinvested in ongoing better bank initiatives NIM 2.74% NCO ratio 0.22% 1 Non-GAAP measures that management believes aid in the discussion of results. See Appendix for Non-GAAP reconciliation 2 All pre-provision net revenue (PPNR) figures set forth in this row are Non-GAAP measures. See footnote 1 for more information 3 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios. See pages 20, 24, 26 and 27 for more information

6 Balance Sheet Highlights COD – Cost of Deposits 1 Yield is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135%
Loans $ in billions; Period End Balances Investment Securities $ in billions; Period End Balances Deposits $ in billions; Period End Balances
Average Loans $ in billions Average Investment Securities $ in billions Average Deposits $ in billions
(3)% 6.24% 6.39% 6.44% Yield1 1% 1% 3.76% 3.68% 3.63% Yield1 (2)% 2.75% 2.79% 2.79% COD (1)% (1)% +5 bps Flat$17.0 $17.2 $17.3 1Q24 2Q24 3Q24 $6.7 $6.6 $6.3 1Q24 2Q24 3Q24 $22.4 $21.8 $21.9 1Q24 2Q24 3Q24 $16.9 $17.1 $17.2 1Q24 2Q24 3Q24 $6.8 $6.6 $6.4 1Q24 2Q24 3Q24 $22.2 $22.0 $21.7 1Q24 2Q24 3Q24 COD – Cost of Deposits 1 Yield is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135%

Income Statement Highlights 7 $151.9 $153.9 $157.7 1Q24 2Q24 3Q24 $38.9 $40.8 $24.7 $40.4 $41.9 $46.0 1Q24 2Q24 3Q24 Net Income Adjusted Net Income2 $195.1 $197.2 $174.8 $195.1 $197.2 $203.2 1Q24 2Q24 3Q24 Total Revenue Adjusted Revenue2 $55.2 $57.9 $37.6 $57.2 $59.4 $66.4 1Q24 2Q24 3Q24 PPNR2 Adjusted PPNR2 $139.9 $139.4 $137.2 $137.9 $137.8 $136.8 1Q24 2Q24 3Q24 Noninterest Expense Adjusted Noninterest Expense2 $0.31 $0.32 $0.20 $0.32 $0.33 $0.37 1Q24 2Q24 3Q24 Diluted EPS Adjusted Diluted EPS2 (1)% PPNR – Pre-provision net revenue NIE – Noninterest Expense EPS – Earnings per Share 1 NIM is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135% 2 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation

Net Interest Income and Margin (FTE) 8 $159.9 $162.1 $158.3 $160.5 $164.1 3Q23 4Q23 1Q24 2Q24 3Q24 6.08 6.20 6.24 6.39 6.44 3.08 3.67 3.76 3.68 3.63 2.37 2.58 2.75 2.79 2.79 5.60 5.79 5.85 5.84 5.79 3Q23 4Q23 1Q24 2Q24 3Q24 Loan Yield (FTE) Securities (FTE) Cost of Deposits Other Borrowings $8.8 $7.0 $5.8 $5.1 $4.6 4Q24 1Q25 2Q25 3Q25 4Q25 Other â‘ Net interest income (FTE) up $3.6 million, or 2 percent on a linked quarter basis â‘ NIM at 2.74 percent, up 5 bps from 2Q24 â‘ Bond sale aided NIM by 3 bps in the quarter â‘ Asset portion of the balance sheet (3Q24 vs 2Q24) â–ª +5 bps increase on yield on loans â–ª +4 bps increase on yield on earnings assets â–ª -3% decrease in average securities â‘ Liability portion of balance sheet (3Q24 vs 2Q24) â–ª Cost of deposits were flat â–ª -5 bp decrease on rate of other borrowings â‘ Remaining balance of purchase accounting accretion at 9/30/24 was $9.0 million FTE – Fully taxable equivalent using an effective tax rate of 26.135% EA – Earnings assets Totals may not foot due to rounding 1 Estimated swap income based on projected forward effective fed funds rates as of October 1, 2024. Does not include potential impact of hedge ineffectiveness that is recorded in interest income. Under the terms of the swap agreement, the Company receives Effective Fed Funds rate and pays a fixed rate of approximately 1.21% Net Interest Margin Evolution Estimated Future Swap Income1 $ in millions; Based on Forward Fed Funds rates Highlights â‘ Net interest income (FTE) up $3.6 million, or 2 percent on a linked quarter basis â‘ NIM at 2.74 percent, up 5 bps from 2Q24 â‘ Bond sale aided NIM by 3 bps in the quarter â‘ Asset portion of the balance sheet (3Q24 vs 2Q24) â–ª +5 bps increase on yield on loans â–ª +4 bps increase on yield on earnings assets â–ª -3% decrease in average securities â‘ Liability portion of balance sheet (3Q24 vs 2Q24)â–ª Cost of deposits were flatâ–ª -5 bp decrease on rate of other borrowings â‘ Remaining balance of purchase accounting accretion at 9/30/24 was $9.0 million

Noninterest Income 3Q24 $ in millions Reported Adjusted1 Service charges on deposit accounts $ 12.7 $ 12.7 Wealth management fees 8.2 8.2 Debit and credit card fees 8.1 8.1 Mortgage lending income 2.0 2.0 Bank owned life insurance 3.8 3.8 Other service charges and fees 2.4 2.4 Other 8.3 8.3 45.5 45.5 Gain (loss) on sale of securities (28.4)— Total noninterest income $ 17.1 $ 45.5 Adjusted 3Q24 vs Adjusted 2Q24 Adjusted 3Q24 vs Adjusted 3Q23 $ 0.5 4 % $ 0.3 2 % —(1) 0.5 7 — 0.4 6 —(1) (0.2) (9) (0.1) (3) 0.7 21 —1 0.1 7 1.9 30 0.9 12 2.2 5 2.7 6 — — $ 2.2 5 % $ 2.7 6 % Adjusted Total Revenue Per Employee (FTE)1 ($ in thousands) $65.3 $65.8 $65.3 $66.6 $68.4 3Q23 4Q23 1Q24 2Q24 3Q24 Adjusted Noninterest Income to Adjusted Total Revenue1 21.8% 21.3% 22.1% 22.0% 22.4% 3Q23 4Q23 1Q24 2Q24 3Q24 Adjusted Total Revenue Per Avg. Diluted Share1 ($ in thousands) $1.55 $1.57 $1.55 $1.57 $1.61 3Q23 4Q23 1Q24 2Q24 3Q24 Totals may not foot due to rounding FTE – Full-time equivalent 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 9

$ in millions Reported Adjusted1 Salaries and employee benefits $ 69.2 $ 69.2 ($1.4) (2) % $ 3.4 5 % Occupancy expense, net 12.2 12.0 0.3 2 0.1—Furniture and equipment 5.6 5.6 — 0.5 10 Deposit insurance 5.6 5.6 0.2 3 0.9 19 OREO and foreclosure expense 0.1 0.1—(26) (0.1) (62) Other 44.5 44.4 — 2.3 5 Total noninterest expense $137.2 $136.8 ($1.0) (1) % $ 6.9 5 % 3Q24 Adjusted 3Q24 vs Adjusted 2Q24 3Q23 3,005 3,007 2,989 2,961 2,972 3Q23 4Q23 1Q24 2Q24 3Q24 Employees (FTE) 61.9% 62.9% 66.4% 65.7% 63.4% 3Q23 4Q23 1Q24 2Q24 3Q24 Adjusted Efficiency Ratio1 1.87% 1.92% 2.03% 2.03% 2.00% 3Q23 4Q23 1Q24 2Q24 3Q24 Adjusted Noninterest Expense as a Percentage of Total Average Assets1 10 Noninterest Expense Note: Numbers may not add due to rounding NM – not meaningful FTE – full-time equivalent 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 232 234 233 234 234 3Q23 4Q23 1Q24 2Q24 3Q24 # of Financial Centers Highlights â‘ Adjusted noninterest expense1 down 1% from 2Q24 levels primarily as a result of incentive compensation accrual adjustments â‘ Adjusted 3Q24 noninterest expense as a percentage of average assets1 at 2.00 percent, compared to 2.03 percent for 2Q24 â‘ Headcount down 1.1 percent vs a year ago and down 7.3 percent from 3Q22 â‘ Renewal of top vendor contracts has resulted in meaningful cost savings 10

Deposits, Securities, Liquidity, Interest Rate Sensitivity and Capital simmons first national corporation

Deposits Deposit Mix $ in billions; Period End Balances $22.2 $22.2 $22.4 $21.8 $21.9 $3.3 $2.9 $3.0 $2.9 $3.4 $3.2 $3.3 $3.5 $3.3 $3.2 $3.3 $3.5 $3.5 $3.4 $3.3 $7.9 $8.2 $8.1 $8.0 $8.0 $4.5 $4.3 $4.2 $4.2 $4.1 3Q23 4Q23 1Q24 2Q24 3Q24 Noninterest Bearing Interest Bearing Transactions Time Deposits Public Funds Brokered Deposits Highlights Total deposits of $21.9 billion, up $95 million from 2Q24 levels Cost of deposits flat on a linked quarter basis Cost of deposits peaked in June, prior to the Fed rate cut Brokered deposits utilized to offset maturing FHLB advances as brokered    market pricing reflected probability of Fed rate cuts Consumer checking households up on a year-to-date basis ~79% of deposits are FDIC insured or are collateralized deposits2 Linked Quarter Deposit Change1 $ in millions; Period End Balances Total Deposits $95 Noninterest Bearing Transaction Accounts $(54) Interest Bearing Transaction Accounts $(3) Time Deposits $(143) Public Funds $(127) Brokered Deposits (MM & CDs) $422 Evolution of Funding Rates 51% deposit beta during this cycle3 5.26% 5.33% 5.33% 5.33% 5.27% 4.99% Interest Bearing Deposits 4.52% Cost of Deposits Avg Fed Funds Rate 3.65% 3.48% 3.53% 3.52% 3.31% 3.06% 2.57% 2.20% 2.10% 2.75% 2.79% 2.79% 1.41% 2.58% 2.37% 1.96% 0.65% Cost of deposits flat on 1.58% 1.02% a linked quarter basis 0.47% 1Q22 2Q22 3Q22 4Q22 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24 3Q24 Source: Average Fed Funds rate based on data from www.macrotrends.net 1 Linked quarter growth is 3Q24 vs 2Q24. The categories titled “Noninterest Bearing Transaction Accounts,” “Interest Bearing Transaction Accounts” and “Time Deposits” exclude public funds and brokered deposits, which are each shown as separate categories 2 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 12 3 Deposit beta calculated as change in cost of deposits from 1Q22 to 3Q24 divided by the change in quarterly average Federal Funds Effective rate for 1Q22 vs 3Q24

Securities: Targeted goal of securities to earnings assets in mid-teens 3Q24 Targeted Securities Sale Size of targeted sale $252 million Weighted average yield ~1.29% 3Q24 earnings impact $21.0 million after-tax loss EPS impact $0.17 Estimated annual impact $9.0 million net interest income (based on rates at time of execution) NIM impact 7 bps Use of proceeds Pay down higher rate wholesale funding 10-Year Treasury Yield 4.50% 4.35% 4.20% 4.05% Well prepared to quickly take advantage of opportunities given prevailing market conditions that add economic value 3.90% Executed bond 3.75% sale on 8/2/24 Securities Portfolio by Type 8% 8% 41% 43% Treasury/Agency States and Political Subdivisions MBS/CMO Corporate & Other Securities Portfolio Summary Securities Portfolio Bond Ratings2 $ in millions Yield (FTE)1 Effective Duration At September 30, 2024 At September 30, 2024 HTM AFS    HTM     AFS    HTM    AFS Fixed Rate U.S. Guaranteed/GSE $1,558 $1,571 Municipal 3.27% 3.29% 13.11 12.81 Aaa/AAA 472 326 MBS/CMO 3.03 1.43 5.87 4.30 Aa/AA 1,153 526 Treasury/Agency 2.35 2.94 8.91 0.43 A 298 84 Corporate 4.08 6.10 4.41 1.31 Baa/BBB 162 173 Other 2.35 1.66 18.36 3.66 Not Rated 16 11 Variable Rate—5.42 — Total $3,662 $2,691 Total 3.12% 3.24% 9.88 5.91 Fair value $3,110 $2,691 FTE – fully taxable equivalent using an effective tax rate of 26.135% Data presented on this slide is as of September 30, 2024, unless otherwise noted 1 Effective yield of securities portfolio at 9/30/24, excluding AOCI impact of HTM transfers made during Q2 22 2 Bond ratings reflect highest rating by Moody’s Investors Service, Inc., Standard & Poor’s or Fitch Ratings6/3/2024 6/5/2024 6/7/2024 6/9/2024 6/11 2024 6/13/2024 6/15/2024 6/17/2024 6/19/2024 6/21/2024 6/23/2024 6/25/2024 6/27/2024 6/29/2024 7/1/2024 7/3/2024 7/5/2024 7/7/2024/7/9/2024 7/11/2024 7/13/2024 7/15/2024 7/17/2024 7/19/2024 7/21/2024 7/23/2024 7/25/2024 7/27/2024 7/29/2024 7/31/2024 8/2/2024 8/4/2024 8/6/2024 8/8/2024 13

Liquidity: Solid liquidity position and access to additional sources Cash and Cash Equivalents + Variable Rate Securities $ in millions $1,824 $1,301 $1,245 $1,166 $1,145 4Q22 4Q23 1Q24 2Q24 3Q24 Cash & Cash Equivalents Variable Rate Securities Investment Securities – Amortized Cost3 $ in millions (23)% $8,660 $8,091 $7,236 $7,102 $6,941 $6,636 4Q21 4Q22 4Q23 1Q24 2Q24 3Q24 Additional Liquidity Sources $ in millions FHLB borrowing availability $ 4,955 Unpledged securities 4,110 Fed Funds lines and Fed Discount Window 2,109 Total at 9.30.24    $11,174 Uninsured, non-collateralized deposits2    $4,659 Coverage ratio    2.4x Loan to Deposit Ratio Period End Balances Peer 83.0%    85.0%    85.6%    86.3%    Median1 78.7% 79.0% 75.7% 76.1% 71.6% 4Q22 4Q23 1Q24 2Q24 3Q24 Borrowed Funds as a Percent of Total Liabilities Period End Balances 12.6% 10.0% 10.4% 8.9% 7.4% 5.7% 5.9% 6.2% 5.4% 2018 2019 2020 2021 2022 2023 1Q24 2Q24 3Q24 1 Source: S&P Global Market Intelligence. Represents peer median loan to deposit ratio. Peer group includes ABCB, AUB, OZK, BOKF, CADE, CBSH, FBK, HWC, HTLF, HOMB, IBTX, ONB, PNFP, PB, RNST, SSB, SNV, TRMK, UMBF, UCB 2 Uninsured, non-collateralized deposits represent uninsured deposits of Simmons Bank, less the uninsured portion of collateralized deposits, and deposit balances of SFNC subsidiaries. See appendix for Non-GAAP reconciliation 14 3 Does not include the unrealized gain (loss) on AFS investments securities of $(286) million as of September 30, 2024, $(370) million as of June 30, 2024, $(367) million as of March 31, 2024, $(358) million as of December 31, 2023, $(479) million as of December 31,    2022 and $(17) million as of December 31, 2021.

Interest Rate Sensitivity: Attractively positioned for a lower interest rate environment Loan Portfolio – Repricing and Maturity (contractual) At September 30, 2024 In millions Repricing Term Rate Structure 3 mo 3-12    1-3    3-5    Over 5 Total Variable Fixed or less mo    years years years RE—Construction 2,229.4    152.0    302.9    103.5    8.5 2,796.4 2,199.5    596.9 RE—Commercial 2,336.0    759.3 3,073.5 1,076.5    747.1 7,992.4 2,711.1 5,281.3 RE—Single-Family    513.6    251.5    625.8    468.9    864.8 2,724.6 1,389.1 1,335.6 Commercial 1,374.6    135.5    471.4    366.1    119.7 2,467.3 1,459.3 1,008.0 Consumer    206.9    13.9    44.9    15.9    10.0    291.6    198.5    93.1 Other1    666.7    26.6    61.8    69.0    239.5 1,063.6    659.9    403.7 Total 7,327.2 1,338.9 4,580.5 2,099.8 1,989.5 17,336.0 8,617.3 8,718.7 Weighted average rate 2 7.91% 5.69% 4.94% 5.97% 4.60% 6.27% 7.41% 5.23% CD Maturities (over the next 12 months) $ in millions Weighted Average Rates    4.54%    5.13%    4.13%    4.93%    3.93%    4.98%    3.68%    4.57% $1,814.0 $1,220.3 $1,094.1 $727.2 $502.7 $263.0 $328.2 $183.2 4Q24 1Q25 2Q25 3Q25 Other CDs Brokered CDs Additional Interest Rate Sensitivity Factors ~$115 million of projected securities principal maturities per quarter3 ~$2.4 billion of projected cash flows from fixed rate loans at a weighted average rate of 6.01%4 ~$1.0 billion of FHLB advances maturing at a weighted average rate of 5.04% before the end of 2024 ~26% of core interest bearing deposits5 are tied to index rates, principally Fed Funds target rate Balance Sheet Interest Rate Sensitivity Over the next 12 months (estimated) Immediate change in interest rates Estimated NII sensitivity given immediate, parallel shift in interest rates across the yield curve with a static balance sheet 2.04% 1.59% 0.68% D125 bps    D100 bps    D50 bps Gradual change in interest rates Estimated NII sensitivity given gradual, parallel shift in interest rates across the yield curve with a static balance sheet 0.38% 0.37% 0.29% D125 bps    D100 bps    D50 bps * Assumptions used in balance sheet interest rate sensitivity estimates under a gradual decrease in interest rates include the following rate cuts at the FOMC meetings: Down 50 bps – 25 bp decrease in November and December 2024 Down 100 bps – 25 bp decrease in November and December 2024, and March and    May 2025 Down 125 bps – 25 bp decrease in November and December 2024, and March, May    and July 2025 Totals may not add due to rounding 1 Other includes agriculture, mortgage warehouse and other loans 2 Weighted average rates do not include mortgage warehouse and credit card portfolios 15 3 Projections over the next 12 months 4 Cash flows from fixed rate loans over the next 12 months includes prepayment assumptions and are based on the forward rate curve    5 Core interest bearing deposits includes savings, money market, checking and customer CDs. Does not include brokered CDs

Capital: Focused on maintaining a strong capital position and tangible book value per share Tier 1 Leverage Ratio1 CET 1 Capital Ratio1 Tier 1 Risk-Based Capital Ratio1 Total Risk-Based Capital Ratio1 12.02% 12.00% 12.06% 12.02% 12.00% 12.06% 14.27% 14.17% 14.25% 9.31% 9.49% 9.57% 3Q23 2Q24 3Q24 3Q23 2Q24 3Q24 3Q23 2Q24 3Q24 3Q23 2Q24 3Q24 WELL CAPITALIZED WELL CAPITALIZED WELL CAPITALIZED WELL CAPITALIZED 5.0% 6.5% 8.0% 10.0% Book Value Per Common Share1 Tangible Book Value Per Common Share 1,2 +7% +14% $27.56 $28.11 $16.78 $26.26 $16.20 $14.77 2% 4% 3Q23 2Q24 3Q24 3Q23 2Q24 3Q24 Capital Ratios (at 9/30/24) CET 1 Capital Ratio Total Risk-Based Capital Ratio 12.06% 14.25% Equity to Assets Tangible Common Equity Ratio2 12.94% 8.15% Share Repurchase Program3 No shares were repurchased during the third quarter of 2024 $175M remaining authorization under January 2024 program 1 3Q24 data as of September 30, 2024, 2Q24 data as of June 30, 2024, and 3Q23 data as of September 30, 2023 2 Non-GAAP measures that management believes aid in the discussion of results. See Appendix for Non-GAAP reconciliation 3 Market conditions and our capital needs (among other things) will drive decisions regarding additional, future stock repurchases

AOCI: Recapture would have a significant positive impact on TCE and TBVPS AOCI Evolution and Projections $ in millions AOCI Position 9/30/23 12/31/23 3/31/24 6/30/24 9/30/24 $(336) $(404) $(408) $(405) 17% $(544) 38% Projected AOCI “Burn” Down AOCI Flat Rates YE YE YE 9/30/24 2024 2025 2026 $(266) $(294) $(336) $(326) ~3% ~13% ~21% Flat Rates: projected AOCI burn down assumes interest rates remain at 9/30/24 levels No additional bond sales

Loan Portfolio simmons first national corporation

Loans: Well-diversified, granular portfolio and conservative credit culture Loan Portfolio Waterfall $ in millions Funded loans Paydowns/ /advances payoffs Total loans Total loans at 6/30/24 at 9/30/24 $17,192 $1,877 $(1,733) $17,336 Unfunded Commitments $ in millions $4,049 $3,880 $3,875 $3,746 $3,681 90% variable rate • 63% tied to Prime • 37% tied to SOFR 3Q23 4Q23 1Q24 2Q24 3Q24 RE—Construction Commercial RE—Single Family RE—Commercial Agriculture Consumer/Other Linked Quarter Loan Growth $ in millions Total Loans $144 RE – Commercial $233 RE – Construction $(261) Commercial1 $(2) RE – Single Family $59 Consumer & Other $8 Agricultural $29 Mortgage Warehouse $94 Run-Off Portfolio2 $(16) Highlights Well-diversified, granular portfolio with no significant industry or geographic concentrations Focused on maintaining conservative underwriting standards and structure guidelines while emphasizing prudent pricing discipline Minimal exposure to Shared National Credits (SNC) SNC totaled ~1% of total loans Additional banking relationships with all borrowers No exposure to Hurricane Helene impacted areas; no significant exposure to Hurricane Milton impacted areas 1 Commercial loan growth excludes the impact of loans included in the run-off portfolio 2 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios 19

Loans: Pipelines represent opportunities that meet pricing and disciplined credit appetite Commercial Loan Pipeline by Category $ in millions Opportunity Proposal Ready to Close $1,244 $1,048 $1,013 $1,002 $877 $948 $549 $381 $330 $504 $689 $416 $433 $121 $168 $274 $147 $189 $252 $167 $200 $292 $248 $244 $343 $485 $551 $527 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24 3Q24 Rate Ready to 7.32% 7.94% 8.43% 8.44% 8.38% 8.68% 8.31% Close1 Mortgage Loan Volume $ in millions Mortgage Closed Loan Volume Mortgage Pipeline Volume $32 $36 $25 $24 $27 $29 $152 $17 $106 $101 $111 $78 $89 $69 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24 3Q24 Highlights Continued focus on maintaining prudent underwriting standards and pricing discipline $549 million of ready to close loans in the commercial pipeline with a rate1 of 8.31% Mortgage loan originations in 3Q24 85% purchase 15% refinance 1 Rate ready to close represents the weighted average rate on commercial loans that are ready to close and does not include fees, including FAS 91 fees, associated with those commercial loans 20

Loans: Conservative LTVs underpin prudent underwriting standards in key sectors Loan Portfolio – Geographic diversification Office (non-owner occupied permanent) Key Statistics At 9/30/24 By State By State NPL Ratio2 0.81% 13% 2% Past Due 30+ Days 0.03% 2% 19% Average Loan Size $2.2M 44% 33% 11% $0.8B Median Loan Size $0.5M 2% Number of Loans <$1M 64% 5% 1 12% $16.7B Average LTV 48.0% 16% Weighted Average LTV 54.5% 9% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Multifamily (permanent) Key Statistics At 9/30/24 18% 14% By State 9% NPL Ratio 0.01% 10% Texas Arkansas Tennessee Missouri 34% Past Due 30+ Days 0.01% Oklahoma Kansas Other 9% $0.8B Average Loan Size $2.6M Median Loan Size $0.6M 7% % of Total % of Total Top 10 MSAs Number of Loans <$1M 67% Loans1 Commitments1 12% 19% Dallas-Plano-Irving 10.4% 10.5% Average LTV 52.4% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Houston-Sugarland-Baytown 8.9% 8.5% Weighted Average LTV 63.0% Memphis 5.7% 5.7% Retail (non-owner occupied permanent) Key Statistics At 9/30/24 Little Rock-North Little Rock-Conway 5.6% 5.7% By State NPL Ratio 0.51% Nashville-Davidson-Murfreesboro 4.9% 5.7% 16% Fort Worth-Arlington 4.5% 4.4% Past Due 30+ Days 0.46% 6% 46% Fayetteville-Springdale-Rogers 3.2% 2.9% Average Loan Size $1.8M $1.0B Median Loan Size $0.9M St. Louis 2.8% 2.6% 9% Oklahoma City 2.3% 2.1% Number of Loans <$1M 51% 11% Kansas City 1.8% 2.3% Average LTV 48.6% 12% Weighted Average LTV 56.4% Texas Arkansas Tennessee Missouri Oklahoma Other Data shown above as of September 30, 2024 1 Total loans or commitments excluding credit card portfolio and mortgage warehouse 2 Represents a single, non-owner occupied real estate loan for a call center whose business was negatively impacted by Covid 21

Loans: Construction and Land Development Construction and Land Development (CLD) By State % of Total % of Total Key Statistics At 9/30/24 MSAs Loans Commitments NPL Ratio 0.19% Dallas-Plano-Irving 16.3% 15.4% Past Due 30+ Days 0.01% 27% Houston-Sugarland-Baytown 13.8% 11.6% 43% Average Loan Size $1.4M Nashville-Davidson-Murfreesboro 5.4% 8.3% Median Loan Size $0.3M $2.8B Fort Worth-Arlington 4.1% 4.2% Number of Loans <$1M 85% 3% Memphis 3.0% 2.9% Average LTV 55.2% 3% Little Rock-North Little Rock-Conway 2.7% 2.6% Weighted Average LTV 53.3% 3% Kansas City 2.0% 3.1% 12% 9% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other CLD—Multifamily CLD—Industrial Warehouse (non-owner occupied) By State By State Key Statistics At 9/30/24 Key Statistics At 9/30/24 14% NPL Ratio 0.00% NPL Ratio 0.00% Texas Texas 37% 24% Past Due 30+ Days 0.00% Past Due 30+ Days 0.00% Arkansas 12% Tennessee 47% Tennessee Average Loan Size $16.4M Average Loan Size $16.6M $0.9B Median Loan Size $11.1M $0.6B 4% Missouri Kansas Median Loan Size $8.3M 6% 4% Florida Number of Loans <$1M 33% Oklahoma Number of Loans <$1M 34% Other Average LTV 48.2% 7% 17% Florida Average LTV 41.1% 4% 24% Weighted Average LTV 52.5% Weighted Average LTV 41.9% Other Data shown above as of September 30, 2024 22

Loans: Loan portfolio by type and key credit metrics as of June 30, 2024 as of September 30, 2024 % of % of Unfunded Unfunded Balance Total Balance Total Past Due 30+ Days Classified Nonperforming Commitment ACL Commitment $ in millions $ Loans $ Loans $ $ $ $ % Reserve Total Loan Portfolio Credit Card 178 1% 178 1% 2 1 1—3.38% -Consumer – Other 130 1% 114 1% 1 — 27 2.26% 0.93% Real Estate – Construction 3,057 18% 2,796 16%—10 6 1,769 1.24% 1.16% Real Estate – Commercial 7,760 45% 7,993 46% 10 257 27 209 1.29% 0.43% Real Estate—Single-family 2,666 15% 2,725 16% 12 35 31 310 1.45% 0.60% Commercial 2,485 14% 2,467 14% 11 62 36 1,263 1.72% 0.16% Mortgage Warehouse 316 2% 410 2% — — 0.21% -Agriculture 285 2% 314 2%—1 1 102 0.47% 0.11% Other 315 2% 339 2% ——1 0.87% 0.10% Total Loan Portfolio 17,192 100% 17,336 100% 36 366 102 3,681 1.35% 0.70% Loan Concentration (Holding Company Level) C&D 103% 94% CRE 277% 272% Select Loan Categories Retail 1,230 7% 1,211 7% 4 23 5 89 1.27% 0.69% Nursing / Extended Care 255 1% 244 1%—101—1 7.03% 0.06% Healthcare 602 4% 608 4%—4 4 110 0.91% 0.23% Multifamily 1,671 10% 1,754 10%—7—590 0.92% 0.66% Hotel 649 4% 651 4%—65—102 2.82% 0.94% Restaurant 541 3% 548 3%—36 4 42 2.90% 0.36% NOO Office 906 5% 866 5%—11 7 130 2.10% 1.35% NOO Industrial Warehouse 1,549 9% 1,530 9%—1—296 0.14% 0.25% Run-Off Portfolio1 103 1% 87 1% 1 8 7 9 7.49% 0.02% 1 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios 23

Simmons first national corporation Credit Quality

Credit Quality: Nonperforming and past due loans Nonperforming Loans Evolution Highlights $ in millions; FTE Decrease in nonperforming loans driven by a $9 million decrease in run-off portfolio that included $3.5 million charge-off primarily related to a single, previously identified nonperforming loan “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios. Run-off portfolio totaled $87 million at end of 3Q24, down from $103 million at the end of 2Q24 Have modified one loan (single family residential) for a borrower who was experiencing financial difficulty during 2024 2Q24 RE—RE—Run-Off 3Q24 Classified loans relatively unchanged from 2Q24 levels Commercial Construction Portfolio Nonperforming Loans / Total Loans1 Nonperforming Assets / Total Assets1 Past Due 30-89 days / Total Loans1 Strategic decision to de-risk certain elements of the loan portfolio through planned exit of particular acquired non-relationship credits Annual Quarterly Annual Quarterly Annual Quarterly 0.83% 0.96% 0.81% 0.64% 0.64% 0.55% 0.67% 0.65% 0.63% 0.60% 0.57% 0.59% 0.50% 0.50% 0.41% 0.39% 0.49% 0.38% 0.33% 0.33% 0.29% 0.32% 0.37% 0.31% 0.24% 0.21% 0.24% 0.24% 0.20% 0.19% 0.11% 0.11% 0.23% 0.18% 0.19% 0.15% 2017 2018 2019 2020 2021 2022 2023 3Q23 4Q23 1Q24 2Q24 3Q24 2017 2018 2019 2020 2021 2022 2023 3Q23 4Q23 1Q24 2Q24 3Q24 2017 2018 2019 2020 2021 2022 2023 3Q23 4Q23 1Q24 2Q24 3Q24 Source: S&P Global Market Intelligence 2017 – 2023; Company Reports 1 As of December 31, for each respective year shown above; quarterly data as of the end of the quarter for each respective period 25

Credit Quality: Loan loss provision and net charge-offs Net Charge-Offs to Average Loans1 Highlights Annual Quarterly Provision for credit losses on loans exceeded net charge-offs by $2.8 million during 3Q24 NCO ratio of 22 bps in 3Q24; 9 bps associated with run-off portfolio and 3 bps associated 0.45% with credit card portfolio 0.31% 0.24% 0.28% 0.21% 0.19% 0.22% 0.19% 9 bps of NCO ACL to total loans ended 3Q24 at 1.35%, up 1 bp from 2Q24 levels 0.12% 0.09% ratio associated 0.13% with run-off 0.11% portfolio 2017 2018 2019 2020 2021 2022 2023 3Q23 4Q23 1Q24 2Q24 3Q24 Loan Loss Provision and Net Charge-Offs $ in millions Credit Card Portfolio Net Charge-Off Ratio1 $20.2 Annual Quarterly 3.23% 2.88% 2.49% 2.15% 2.19% $11.6 $12.1 1.61% 1.64% 1.86% 2.50% $11.2 $11.1 1.60% $10.2 1.40% 1.44% $8.1 $9.3 $8.1 $3.5 million of $4.5 net charge-offs associated with 2017 2018 2019 2020 2021 2022 2023 3Q23 4Q23 1Q24 2Q24 3Q24 run-off portfolio 3Q23 4Q23 1Q24 2Q24 3Q24 Key Credit Metrics: Average FICO Scores 751 Provision for credit losses on loans Net Charge-Offs Balance Weighted Average FICO Score 744 Line Utilization 18% Source: S&P Global Market Intelligence 2017 – 2023 1 Net charge-offs to average loans for the full-year for each respective year shown above; quarterly annualized data for each respective quarter 26

ACL: Reflects current economic forecast and composition of loan portfolio ACL / Loans (%) and ACL ($)1 $ in millions Allowance for Credit Losses on Loans and Loan Coverage $250 1.85% 2.00% 1.52% 1.71% ACL / $225 1.80% ACL $200 1.60% Loans 1.34% 1.34% 1.35% $ in millions 1.34% $175 1.22% 1.40% $150 1.20% ACL as of 6/30/23 $ 210.0 1.25% $125 1.00% $100 0.80% 3Q23 Provision 20.2 $75 0.60% 3Q23 Net Charge-Offs (11.7) $50 0.40% ACL as of 9/30/23 $ 218.5 1.30% $25 $220 $238 $205 $197 $225 $227 $230 $233 0.20% $0 0.00% 4Q23 Provision 11.2 1/1/20 CECL 2020 2021 2022 2023 1Q24 2Q24 3Q24 Adoption 4Q23 Net Charge-Offs (4.5) ACL as of 12/31/23 $ 225.2 1.34% ACL METHODOLOGY AS OF 9/30/24: Moody’s September 2024 scenarios with management’s weighting: 1Q24 Provision 10.2 Baseline (75%) / S1 (15%) / S3 (10%) 1Q24 Net Charge-Offs (8.0) Total credit coverage / total commitments: 1.23% ACL as of 3/31/24 $ 227.4 1.34% 2Q24 Provision 11.1 Reserve for Unfunded Commitments 2Q24 Net Charge-Offs (8.1) As of As of As of As of As of $ in millions 9/30/23 12/31/23 3/31/24 6/30/24 9/30/24 ACL as of 6/30/24 $ 230.4 1.34% Unfunded Commitments $4,049 $3,880 $3,875 $3,746 $3,681 3Q24 Provision 12.1 3Q24 Net Charge-Offs (9.3) Reserve for Unfunded Commitments $25.6 $25.6 $25.6 $25.6 $25.6 Provision for Unfunded Commitments $(11.3) — — ACL as of 9/30/24 $ 233.2 1.35% Reserve / Unfunded Balance 0.63% 0.66% 0.66% 0.68% 0.70% Note: Numbers may not add due to rounding ACL – Allowance for Credit Losses on Loans 1 As of December 31, for each respective year shown above; quarterly data as of the end of the quarter for each respective period 27

Simmons first national corporation Appendix

Select Balance Sheet and Other Data 3Q24 vs 2Q24 3Q24 vs 3Q23 $ in millions, except per share data 3Q24 2Q24 3Q23 $ Change % Change $ Change % Change Period End Balances Total loans $17,336.0 $17,192.4 $16,771.9 $143.6 1 % $564.2 3 % Investment securities 6,349.8 6,571.4 7,100.7 (221.6) (3) (750.9) (11) Total assets 27,269.4 27,369.1 27,564.3 (99.7)— (294.9) (1) Total deposits 21,935.4 21,840.9 22,231.2 94.6— (295.8) (1) Borrowed funds 1,463.2 1,765.3 1,788.4 (302.1) (17) (325.2) (18) Total stockholders’ equity 3,528.8 3,458.9 3,285.6 70.0 2 243.3 7 Average Balances Total loans $17,208.2 $17,101.8 $16,758.6 $106.4 1 % $449.6 3 % Investment securities 6,444.5 6,632.5 7,255.6 (188.0) (3) (811.2) (11) Total assets 27,216.4 27,305.3 27,594.6 (88.8)— (378.2) (1) Total deposits 21,717.4 22,045.5 22,273.5 (328.1) (1) (556.1) (2) Borrowed funds 1,670.5 1,528.5 1,678.4 142.0 9 (7.9)— Total stockholders’ equity 3,505.1 3,451.2 3,371.7 54.0 2 133.5 4 Select Other Data Equity to assets 12.94 % 12.64 % 11.92 % Tangible common equity to tangible assets1 8.15 7.84 7.07 Book value per share $28.11 $27.56 $26.26 $0.55 2 % $1.85 7 % Tangible book value per share1 16.78 16.20 14.77 0.58 4 2.01 14 Allowance for credit losses to total loans 1.35 % 1.34 % 1.30 % Nonperforming loan coverage ratio 229 223 267 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 29

Income Summary 3Q24 Adjusted 3Q24 vs Adjusted $ in millions, except per share data Reported Adjusted1 2Q24 3Q23 Net interest income $157.7 $157.7 $3.8 2 % $4.3 3 % Noninterest income 17.1 45.5 2.2 5 2.7 6 Total revenue 174.8 203.2 6.0 3 7.0 4 Noninterest expense 137.2 136.8 (1.0) (1) 6.9 5 Pre-provision net revenue2 37.6 66.4 7.1 12 0.1— Provision for credit losses on loans 12.1 12.1 1.0 9 4.4 NM Provision for income taxes 0.8 8.3 1.9 30 (1.5) (15) Earnings $ 24.7 $ 46.0 $ 4.1 10 % $(2.8) (6) % Diluted EPS $ 0.20 $ 0.37 $0.04 12 % $(0.02) (5) % Totals may not foot due to rounding NM – Not meaningful 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliation 30 2 All pre-provision net revenue (PPNR) figures set forth in this row are Non-GAAP measures. See footnote 1 for more information

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q $ in thousands, except per share data 2023 2023 2024 2024 2024 Calculation of Adjusted Earnings Net Income $ 47,247 $ 23,907 $ 38,871 $ 40,763 $ 24,740 Certain items Merger related costs 5 — —Branch right sizing, net 547 3,846 236 519 410 Loss (gain) on sale of securities—20,218 — 28,393 Early retirement program 1,557 1,032 219 118 (1) FDIC special assessment—10,521 1,549 283 -Termination of vendor and software services ——615 (13) Tax effect⽹⾠(552) (9,309) (524) (401) (7,524) Certain items, net of tax 1,557 26,308 1,480 1,134 21,265 Adjusted earnings (non-GAAP) $ 48,804 $ 50,215 $ 40,351 $ 41,897 $ 46,005 Calculation of Earnings and Adjusted Earnings per Diluted Share Earnings available to common shareholders $ 47,247 $ 23,907 $ 38,871 $ 40,763 $ 24,740 Diluted earnings per share $ 0.37 $ 0.19 $ 0.31 $ 0.32 $ 0.20 Adjusted earnings available to common shareholders (non-GAAP) $ 48,804 $ 50,215 $ 40,351 $ 41,897 $ 46,005 Adjusted diluted earnings per share (non-GAAP) $ 0.39 $ 0.40 $ 0.32 $ 0.33 $ 0.37 (1) Effective tax rate of 26.135% 31

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q $ in thousands 2023 2023 2024 2024 2024 Calculation of Pre-Provision Net Revenue (PPNR) Net interest income $ 153,433 $ 155,628 $ 151,906 $ 153,905 $ 157,712 Noninterest income 42,777 21,974 43,184 43,299 17,130 Less: Noninterest expense 131,998 148,139 139,879 139,354 137,193 Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 64,212 $ 29,463 $ 55,211 $ 57,850 $ 37,649 Calculation of Adjusted Pre-Provision Net Revenue Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 64,212 $ 29,463 $ 55,211 $ 57,850 $ 37,649 Plus: (Gain) loss on sale of securities—20,218 — 28,393 Plus: Merger related costs 5 — —Plus: Branch right sizing costs, net 547 3,846 236 519 410 Plus: FDIC special assessment—10,521 1,549 283 -Plus: Early retirement program 1,557 1,032 219 118 (1) Plus: Termination of vendor and software services — — — 615 (13) Adjusted Pre-Provision Net Revenue (non-GAAP) $ 66,321 $ 65,080 $ 57,215 $ 59,385 $ 66,438 Calculation of Book Value and Tangible Book Value per Share Total common stockholders’ equity $ 3,285,555 $ 3,426,488 $ 3,439,126 $ 3,458,869 $ 3,528,833 Intangible assets: Goodwill (1,320,799) (1,320,799) (1,320,799) (1,320,799) (1,320,799) Other intangible assets (116,660) (112,645) (108,795) (104,943) (101,093) Total intangible assets (1,437,459) (1,433,444) (1,429,594) (1,425,742) (1,421,892) Tangible common stockholders’ equity (non-GAAP) $ 1,848,096 $ 1,993,044 $ 2,009,532 $ 2,033,127 $ 2,106,941 Shares of common stock outstanding 125,133,281 125,184,119 125,419,618 125,487,520 125,554,598 Book value per common share $ 26.26 $ 27.37 $ 27.42 $ 27.56 $ 28.11 Tangible book value per common share (non-GAAP) $ 14.77 $ 15.92 $ 16.02 $ 16.20 $ 16.78 32

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q $ in thousands, except number of employees (FTE) 2023 2023 2024 2024 2024 Calculation of Total Revenue and Adjusted Total Revenue Net Interest Income (GAAP) $ 153,433 $ 155,628 $ 151,906 $ 153,905 $ 157,712 Noninterest Income (GAAP) 42,777 21,974 43,184 43,299 17,130 Total Revenue (non-GAAP) $ 196,210 $ 177,602 $ 195,090 $ 197,204 $ 174,842 Total Revenue (non-GAAP) $ 196,210 $ 177,602 $ 195,090 $ 197,204 $ 174,842 Less: Gain (loss) on sales of securities — (20,218) — — (28,393) Adjusted Total Revenue (non-GAAP) $ 196,210 $ 197,820 $ 195,090 $ 197,204 $ 203,235 Employees (FTE) 3,005 3,007 2,989 2,961 2,972 Total Revenue per Employee (FTE) $ 65.29 $ 59.06 $ 65.27 $ 66.60 $ 58.83 Adjusted Total Revenue per Employee (FTE) $ 65.29 $ 65.79 $ 65.27 $ 66.60 $ 68.38 Calculation of Adjusted Noninterest Income Noninterest Income (GAAP) $ 42,777 $ 21,974 $ 43,184 $ 43,299 $ 17,130 Less: Gain (loss) on sale of securities — (20,218) — — (28,393) Adjusted Noninterest Income (non-GAAP) $ 42,777 $ 42,192 $ 43,184 $ 43,299 $ 45,523 Calculation of Noninterest Income to Total Revenue Noninterest Income to Total Revenue 21.80% 12.37% 22.14% 21.96% 9.80% Adjusted Noninterest Income to Adjusted Total Revenue (non-GAAP) 21.80% 21.33% 22.14% 21.96% 22.40% Calculation of Total Revenue and Adjusted Revenue Per Share Average Diluted Shares Outstanding 126,283,609 125,609,265 125,661,950 125,758,166 125,999,269 Total Revenue per Average Diluted Shares Outstanding $ 1.55 $ 1.41 $ 1.55 $ 1.57 $ 1.39 Adjusted Total Revenue per Average Diluted Shares Outstanding (non-GAAP) $ 1.55 $ 1.57 $ 1.55 $ 1.57 $ 1.61 FTE – Full time equivalent 33

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q $ in thousands 2023 2023 2024 2024 2024 Calculation of Adjusted Noninterest Expense Noninterest Expense (GAAP) $ 131,998 $ 148,139 $ 139,879 $ 139,354 $ 137,193 Less: Merger related costs 5 — —Less: Branch right sizing expense 547 3,846 236 519 410 Less: Early retirement program 1,557 1,032 219 118 (1) Less: FDIC special assessment—10,521 1,549 283 -Less: Termination of vendor and software services — — — 615 (13) Adjusted Noninterest Expense (non-GAAP) $ 129,889 $ 132,740 $ 137,875 $ 137,819 $ 136,797 Calculation of Noninterest Expense to Average Assets Average total assets $ 27,594,611 $ 27,370,811 $ 27,259,399 $ 27,305,277 $ 27,216,440 Noninterest expense to average total assets 1.90% 2.15% 2.06% 2.05% 2.01% Adjusted noninterest expense to average assets (non-GAAP) 1.87% 1.92% 2.03% 2.03% 2.00% Calculation of Efficiency Ratio and Adjusted Efficiency Ratio Noninterest Expense (efficiency ratio numerator) $ 131,998 $ 148,139 $ 139,879 $ 139,354 $ 137,193 Total Revenue $ 196,210 $ 177,602 $ 195,090 $ 197,204 $174,842 Fully taxable equivalent adjustment ___ _ _6,515 ___ _ _6,511 ___ _ _6,422 ___ _ _6,576 ___ _ _6,398 Efficiency ratio denominator $ 202,725 $ 184,113 $ 201,512 $ 203,780 $ 181,240 Efficiency ratio (based on GAAP figures) 65.11% 80.46% 69.41% 68.38% 75.70% Adjusted Noninterest Expense (non-GAAP) $ 129,889 $ 132,740 $ 137,875 $ 137,819 $ 136,797 Less: Other real estate and foreclosure expense 228 189 179 117 87 Less: Amortization of intangible assets ___ __ 4,097 ___ __ 4,015 ___ __ 3,850 ___ __ 3,852 ___ __ 3,851 Adjusted efficiency ratio numerator (non-GAAP) $ 125,564 $ 128,536 $ 133,846 $ 133,850 $ 132,859 Adjusted Total Revenue (non-GAAP) (reconciliation shown on page 33) $ 196,210 $ 197,820 $ 195,090 $ 197,204 $ 203,235 Fully taxable equivalent adjustment ___ _ _6,515 ___ _ _6,511 ___ _ _6,422 ___ _ _6,576 ___ _ _6,398 Adjusted efficiency ratio denominator (non-GAAP) $ 202,725 $ 204,331 $ 201,512 $ 203,780 $ 209,633 Adjusted Efficiency Ratio (non-GAAP) 61.94% 62.91% 66.42% 65.68% 63.38% FTE – Full time equivalent Fully taxable equivalent adjustment using an effective tax rate of 26.135% 34

Non-GAAP Reconciliations 3Q 2Q 3Q $ in thousands 2023 2024 2024 Calculation of Adjusted Salaries and Employee Benefits Salaries and employee benefits (GAAP) $ 67,374 $ 70,716 $ 69,167 Less: Early retirement program 1,557 118 (1) Plus: Other — 1 (1) Total Adjusted Salaries and Employee Benefits (non-GAAP) $ 65,817 $ 70,599 $ 69,167 Calculation of Adjusted Deposit Insurance Deposit insurance (GAAP) $ 4,672 $ 5,682 $ 5,571 Less: FDIC special assessment — 283 -Total Adjusted Deposit Insurance (non-GAAP) $ 4,672 $ 5,399 $ 5,571 Calculation of Adjusted Occupancy Expense, Net Occupancy expense, net (GAAP) $ 12,020 $ 11,864 $ 12,216 Less: Branch right sizing expense 78 125 224 Total Adjusted Occupancy Expense (non-GAAP) $ 11,942 $ 11,739 $ 11,992 Calculation of Adjusted Other Noninterest Expense Other noninterest expense (GAAP) $ 42,582 $ 45,352 $ 44,540 Less: Branch right sizing expense 466 392 184 Less: Termination of vendor and software services — 615 (13) Total Adjusted Other Noninterest Expense (non-GAAP) $ 42,116 $ 44,345 $ 44,369 Calculation of Adjusted Provision for Income Taxes Provision for income taxes (GAAP) $ 9,243 $ 5,988 $ 761 Less: Tax effect of certain items (non-GAAP) (reconciliation shown on page 31) (552) (401) (7,524) Adjusted provision for income taxes (non-GAAP) $ 9,795 $ 6,389 $ 8,285 Fully taxable equivalent adjustment using an effective tax rate of 26.135% 35

Non-GAAP Reconciliations 3Q 2Q 3Q $ in thousands 2023 2024 2024 Calculation of Tangible Common Equity (TCE) Total common stockholders’ equity $ 3,285,555 $ 3,458,869 $ 3,528,833 Total assets $ 27,564,325 $ 27,369,072 $ 27,269,404 Less: Intangible assets (1,437,459) (1,425,742) (1,421,892) Total tangible assets $ 26,126,866 $ 25,943,330 $ 25,847,512 Common equity to total assets 11.92% 12.64% 12.94% Tangible common equity to tangible common assets (non-GAAP) 7.07% 7.84% 8.15% Calculation of CET 1 Capital Ratio, Including the Impact of AOCI Total stockholders’ equity $ 3,285,555 $ 3,458,869 $ 3,528,833 CECL transition provision 61,746 30,873 30,873 Disallowed intangible assets, net of deferred tax (1,402,682) (1,391,969) (1,388,549) Unrealized loss (gain) on available for sale securities (AOCI) ____ _ 544,380 ____ _ 405,481 ____ _ 335,861 Total tier 1 capital (CET 1) $ 2,488,999 $ 2,503,254 $ 2,507,018 Total tier 1 capital (CET 1) $ 2,488,999 $ 2,503,254 $ 2,507,018 Less: Unrealized loss (gain) on available for sale securities (AOCI) 544,380 405,481 335,861 Total tier 1 capital, including AOCI (non-GAAP) $ 1,944,619 $ 2,097,773 $ 2,171,157 Risk weighted assets $ 20,703,669 $ 20,856,194 $ 20,790,941 CET 1 capital ratio 12.02% 12.00% 12.06% CET 1 capital ratio, including AOCI 9.39% 10.06% 10.44% FTE—Fully taxable equivalent adjustment using an effective tax rate of 26.135% 36

Non-GAAP Reconciliations 3Q 2Q 3Q $ in thousands 2023 2024 2024 Calculation of Uninsured, Non-Collateralized Deposit Coverage Ratio Uninsured deposits at Simmons Bank $ 8,143,200 $ 8,186,903 $ 8,355,496 Less: Collateralized deposits (excluding portion that is FDIC insured) 2,835,405 2,835,424 2,710,167 Less: Intercompany eliminations ______676,840 ______943,979 ______986,626 Total uninsured, non-collateralized deposits $ 4,630,955 $ 4,407,500 $ 4,658,703 FHLB borrowing availability $ 5,372,000 $ 4,910,000 $ 4,955,000 Unpledged securities 4,124,000 4,145,000 4,110,000 Fed funds lines, Fed discount window and Bank Term Funding Program1 1,951,000 2,065,000 2,109,000 Additional liquidity sources $ 11,447,000 $ 11,120,000 $ 11,174,000 Uninsured, non-collateralized deposit coverage ratio 2.5x 2.5x 2.4x Calculation of Net Charge-Off Ratio Net charge-offs $ 8,077 $ 9,314 Less: Net charge-offs from run-off portfolio ______ 6,700 ______ 3,500 Net charge offs excluding run-off portfolio $ 1,377 $ 5,814 Average total loans $ 17,101,799 $ 17,208,162 Net charge-offs as a percentage of average total loans (annualized) (NCO ratio) 0.19% 0.22% NCO ratio excluding NCOs associated with run-off portfolios (annualized) 0.03% 0.13% FTE—Fully taxable equivalent adjustment using an effective tax rate of 26.135% 1 The Bank Term Funding Program closed for new loans on March 11, 2024. At no time did Simmons borrow funds under this program. 37

Simmons first national corporation Nasdaq: SFNC 3rd Quarter 2024 Earnings Presentation Contents 3 Company Profile 4 3Q24 Financial Highlights 11 Deposits, Securities, Liquidity, Interest Rate Sensitivity and Capital 18 Loan Portfolio 24 Credit Quality 28 Appendix