W&dϬϮ​ǁĂƐ​ǁĞůůͲƚŽůĞƌĂƚĞĚ​ĂŵŽŶŐ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ​ǁŚŽ​ƌĞĐĞŝǀĞĚ​ ĞŶŚĂŶĐĞĚ​ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ • dƐ​ǁĞƌĞ​ƌĞƉŽƌƚĞĚ​ŝŶ​Ăůů​ƉĂƌƟĐŝƉĂŶƚƐ​;Ŷсϱͬϱ​΀ϭϬϬ͘Ϭй΁Ϳ͖​ŵŽƐƚ​;ϯϴͬϰϬ​ĞǀĞŶƚƐͿ​ǁĞƌĞ​ ŵŝůĚͲƚŽͲŵŽĚĞƌĂƚĞ͘​Ɛ​ǁĞƌĞ​ƌĞƉŽƌƚĞĚ​ĨŽƌ​ŽŶĞ​ƉĂƌƟĐŝƉĂŶƚ​;Ŷсϭͬϱ​΀ϮϬ͘Ϭй΁Ϳ​;Table 2Ϳ • KŶĞ​ƉĂƌƟĐŝƉĂŶƚ͕​ƚŚĞ​ĮƌƐƚ​ƚƌĞĂƚĞĚ​;Ŷсϭͬϱ​΀ϮϬ͘Ϭй΁Ϳ͕​ŚĂĚ​ƚǁŽ​ƚƌĞĂƚŵĞŶƚͲƌĞůĂƚĞĚ​Ɛ​ ĂŶĚ​ǁŝƚŚĚƌĞǁ​ĨƌŽŵ​ƚŚĞ​ƐƚƵĚLJ​;Table 2Ϳ • dŚĞ​ĮƌƐƚ​ƉĂƌƟĐŝƉĂŶƚ​ƚƌĞĂƚĞĚ​ǁŝƚŚ​W&dϬϮ​ƌĞĐĞŝǀĞĚ​ϲϬ​ŵŐ​ŽƌĂů​ƉƌĞĚŶŝƐŽŶĞ​ĚĂŝůLJ​ƚŚƌŽƵŐŚ​ ϲϬ​ĚĂLJƐ͘​dŚŝƐ​ƉĂƌƟĐŝƉĂŶƚ​ŚĂĚ​ĂŶ​ĂƐLJŵƉƚŽŵĂƟĐ​ĐĞƌĞďƌĂů​ǀĞŶŽƵƐ​ƐŝŶƵƐ​ƚŚƌŽŵďŽƐŝƐ​;sdͿ​ ŽŶ​DZ/​ĂŶĚ​ĚŝƐƉůĂLJĞĚ​ĂŶ​ŝŶĐƌĞĂƐĞ​ŝŶ​>dͬd​ϳ​ĚĂLJƐ​ĂŶĚ​ϳ​ǁĞĞŬƐ​ƉŽƐƚͲƚƌĞĂƚŵĞŶƚ͕​ǁŚŝĐŚ​ ƌĞƐƉŽŶĚĞĚ​ƚŽ​/s​ƐƚĞƌŽŝĚƐ͘​ŝůŝƌƵďŝŶ​ůĞǀĞůƐ​ƌĞŵĂŝŶĞĚ​ŶŽƌŵĂů​ƚŚƌŽƵŐŚŽƵƚ • &Žƌ​ƉĂƌƟĐŝƉĂŶƚƐ​Ϯ​ƚŚƌŽƵŐŚ​ϱ͕​ƚŚĞ​ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ​ǁĂƐ​ĂĚũƵƐƚĞĚ​ƚŽ​ ϭ​Ő​ŵĞƚŚLJůƉƌĞĚŶŝƐŽůŽŶĞ​/s​ĚĂŝůLJ​ƚŽ​ĚĂLJ​ϯ͕​ĨŽůůŽǁĞĚ​ďLJ​ŽƌĂů​ƉƌĞĚŶŝƐŽŶĞ​ƚŽ​ĚĂLJ​ϲϬ • &Žƌ​ƉĂƌƟĐŝƉĂŶƚƐ​ƌĞĐĞŝǀŝŶŐ​ƚŚĞ​ĂĚũƵƐƚĞĚ​ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ͕​ƚŚĞƌĞ​ǁĞƌĞ​ŶŽ​ ƐƵďƐƚĂŶƟĂů​ŝŶĐƌĞĂƐĞƐ​ŝŶ​ŵĂƌŬĞƌƐ​ŽĨ​ŚĞƉĂƚŽƚŽdžŝĐŝƚLJ​;&ŝŐƵƌĞ​ϯͿ͕​ŶŽ​ĞǀŝĚĞŶĐĞ​ŽĨ​sd​ŽŶ​DZ/͕​ ĂŶĚ​ŶŽ​Ɛ​ƵƉ​ƚŽ​ĚĂLJ​ϯϲϬ Interim Safety and Biomarker Data From upliFT-D Trial of PBFT02 in FTD With GRN Mutations Chavez J,1 Forman M,1 Voss T,1 Triglia P,1 Ni YG,1 Browne SE,1 Quadrini KJ,1 Chou W,1 Ducharme S,2 Irwin DJ,3 Santana I,4 Schulz PE,5 Takada L,6 Tartaglia C,7 de Souza LC8 1 Passage Bio, Inc., Philadelphia, PA, USA; 2 Douglas Mental Health University Institute and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; 3 Perelman School of Medicine at the University of Pennsylvania; University of Pennsylvania Health System, Philadelphia, PA, USA; 4 Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 5 McGovern Medical School, UTHealth Houston, Houston, TX, USA; 6 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; 7 University Health Network and Tanz Centre for Research in Neurodegenerative Diseases, Toronto, Ontario, Canada; 8 Hospital das Clínicas Universidade Federal de Minas Gerais, Belo Horizonte, Brazil ďďƌĞǀŝĂƟŽŶƐ sϭ͕​ĂĚĞŶŽͲĂƐƐŽĐŝĂƚĞĚ​ǀŝƌƵƐ​ϭ͖​>d͕​ĂůĂŶŝŶĞ​ƚƌĂŶƐĂŵŝŶĂƐĞ͖​d͕​ĂƐƉĂƌƚĂƚĞ​ĂŵŝŶŽƚƌĂŶƐĨĞƌĂƐĞ͖​ ďǀ&d͕​ďĞŚĂǀŝŽƌĂů​ǀĂƌŝĂŶƚ​ĨƌŽŶƚŽƚĞŵƉŽƌĂů​ĚĞŵĞŶƚŝĂ͖​Z͕​ůŝŶŝĐĂů​ĞŵĞŶƚŝĂ​ZĂƚŝŶŐ​ĐĂůĞ͖​ &͕​ĐĞƌĞďƌŽƐƉŝŶĂů​ĨůƵŝĚ͖​d͕​ĐŽŵƉƵƚĞƌ​ƚŽŵŽŐƌĂƉŚLJ͖​&d͕​ĨƌŽŶƚŽƚĞŵƉŽƌĂů​ĚĞŵĞŶƚŝĂ͖​&dͲGRN͕​ ĨƌŽŶƚŽƚĞŵƉŽƌĂů​ĚĞŵĞŶƚŝĂ​ǁŝƚŚ​ŐƌĂŶƵůŝŶ​ŵƵƚĂƚŝŽŶ͖​GRN͕​ŐƌĂŶƵůŝŶ͖​/D͕​ŝŶƚƌĂͲĐŝƐƚĞƌŶĂ​ŵĂŐŶĂ͖​ /D͕​/ŶĚĞƉĞŶĚĞŶƚ​ĂƚĂ​DŽŶŝƚŽƌŝŶŐ​ŽŵŵŝƚƚĞĞ͖​/s͕​ŝŶƚƌĂǀĞŶŽƵƐ͖​ůǀWW͕​ůŽŐŽƉĞŶŝĐ​ǀĂƌŝĂŶƚ​ ƉƌŝŵĂƌLJ​ƉƌŽŐƌĞƐƐŝǀĞ​ĂƉŚĂƐŝĂ͖​DZ/͕​ŵĂŐŶĞƚŝĐ​ƌĞƐŽŶĂŶĐĞ​ŝŵĂŐŝŶŐ͖​W͕​ƉĂƌƚŝĐŝƉĂŶƚ͖​W'ZE͕​ƉƌŽŐƌĂŶƵůŝŶ͖​ ƐǀWW͕​ƐĞŵĂŶƚŝĐ​ǀĂƌŝĂŶƚ​ƉƌŝŵĂƌLJ​ƉƌŽŐƌĞƐƐŝǀĞ​ĂƉŚĂƐŝĂ͖​dƐ͕​ƚƌĞĂƚŵĞŶƚͲĞŵĞƌŐĞŶƚ​ĂĚǀĞƌƐĞ​ĞǀĞŶƚƐ͖​ Ɛ͕​ƐĞƌŝŽƵƐ​ĂĚǀĞƌƐĞ​ĞǀĞŶƚƐ͖​K͕​ƐLJƐƚĞŵ​ŽƌŐĂŶ​ĐůĂƐƐ͖​h>E͕​ƵƉƉĞƌ​ůŝŵŝƚ​ŽĨ​ŶŽƌŵĂů͘ ŝƐĐůŽƐƵƌĞƐ :͕​D&͕​ds͕​Wd͕​z'E͕​͕​<:Y͕​ĂŶĚ​t​ĂƌĞ​ĐƵƌƌĞŶƚ​Žƌ​ĨŽƌŵĞƌ​ĞŵƉůŽLJĞĞƐ​ŽĨ​WĂƐƐĂŐĞ​ŝŽ͕​/ŶĐ͘​ WƌĞƐĞŶƚĞĚ​Ăƚ​/&d͕​ĞƉƚĞŵďĞƌ​ϭϵͲϮϮ͕​ϮϬϮϰ͕​ŵƐƚĞƌĚĂŵ͕​dŚĞ​EĞƚŚĞƌůĂŶĚƐ ŽŶƚĂĐƚ͗​ŵĞĚŝŶĨŽΛƉĂƐƐĂŐĞďŝŽ͘ĐŽŵ ĂĐŬŐƌŽƵŶĚ • W&dϬϮ​ŝƐ​Ă​ŶŽŶͲƌĞƉůŝĐĂƟŶŐ​ƌĞĐŽŵďŝŶĂŶƚ​sϭ​ ǀĞĐƚŽƌ͕​ǁŚŝĐŚ​ĐĂƌƌŝĞƐ​Ă​ĐŽĚŽŶͲŽƉƟŵŝnjĞĚ​ƐĞƋƵĞŶĐĞ​ ŽĨ​ƚŚĞ​ŚƵŵĂŶ​GRN​ŐĞŶĞ​ƵŶĚĞƌ​ƚŚĞ​ĐŽŶƚƌŽů​ŽĨ​ƚŚĞ​ ƵďŝƋƵŝƚŽƵƐ​ϳ​ƉƌŽŵŽƚĞƌ​;&ŝŐƵƌĞ​ϭͿ ŽŶĐůƵƐŝŽŶƐ • /D​ĂĚŵŝŶŝƐƚƌĂƟŽŶ​ŽĨ​W&dϬϮ​ƌĞƐƵůƚĞĚ​ŝŶ​Ă​ƌŽďƵƐƚ​ ĂŶĚ​ĚƵƌĂďůĞ​ĞůĞǀĂƟŽŶ​ŽĨ​&​W'ZE​ůĞǀĞůƐ͕​ǁŚŝĐŚ​ǁĂƐ​ ŵĂŝŶƚĂŝŶĞĚ​ƵƉ​ƚŽ​ϭͲLJĞĂƌ​ƉŽƐƚͲƚƌĞĂƚŵĞŶƚ • WůĂƐŵĂ​W'ZE​ůĞǀĞůƐ​ǁĞƌĞ​ŶŽƚ​ŝŵƉĂĐƚĞĚ​ďLJ​W&dϬϮ​ ĂĚŵŝŶŝƐƚƌĂƟŽŶ • /Ŷ​ƚŚĞ​ĨŽƵƌ​ƉĂƌƟĐŝƉĂŶƚƐ​ǁŚŽ​ƌĞĐĞŝǀĞĚ​ƚŚĞ​ƌĞǀŝƐĞĚ​ ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ͕​ƚŚĞƌĞ​ǁĞƌĞ​ŶŽ​Ɛ​ĂŶĚ​ ŶŽ​ĞǀŝĚĞŶĐĞ​ŽĨ​ĐůŝŶŝĐĂůůLJ​ƐŝŐŶŝĮĐĂŶƚ​ŝŵŵƵŶĞ​ƌĞƐƉŽŶƐĞ • 'ŝǀĞŶ​ƚŚĞ​ƌŽďƵƐƚ​&​W'ZE​ƌĞƐƉŽŶƐĞ͕​ŽŚŽƌƚ​Ϯ​ǁŝůů​ ĐŽŶƟŶƵĞ​ƚŽ​ĞǀĂůƵĂƚĞ​ŽƐĞ​ϭ ZĞƐƵůƚƐ WĂƌƟĐŝƉĂŶƚ​ϭ​ƌĞĐĞŝǀĞĚ​ƚŚĞ​ŝŶŝƟĂů​ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ​ĂŶĚ​ĚŝƐƉůĂLJĞĚ​ŵĂƌŬĞĚůLJ​ŝŶĐƌĞĂƐĞĚ​>dͬd​ůĞǀĞůƐ​;>d​ϭϲdž​h>E͖​d​ϰdž​h>EͿ​ ĨŽůůŽǁŝŶŐ​W&dϬϮ​ĂĚŵŝŶŝƐƚƌĂƟŽŶ͕​ǁŚŝĐŚ​ǁĂƐ​ŵĂŶĂŐĞĚ​ǁŝƚŚ​/s​ƐƚĞƌŽŝĚƐ​;ĚĂƚĂ​ŶŽƚ​ƐŚŽǁŶͿ͖​ƉĂƌƟĐŝƉĂŶƚƐ​ϮͲϱ​ƌĞĐĞŝǀĞĚ​ƚŚĞ​ĂĚũƵƐƚĞĚ​ ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ Time (days) 0 60 120 180 240 300 36 0 3 6 9 12 15 18 21 24 27 30 33 360 CSF PGRN, ng/mL ParƟcipant 1 ParƟcipant 2 ParƟcipant 3 ParƟcipant 4 ParƟcipant 5 0 20 40 60 80 100 120 140 160 180 200 Screening Day 1 Dosing Day 7 Unsch. Day 13 Unsch. Day 16 Day 30 Day 42 Unsch. Day 53 Unsch. Day 55 Unsch. Day 64 Unsch. Day 71 Unsch. Day 78 Day 90 Day 120 Day 180 Day 240 Day 300 Day 360 ALT (U/L) ALT (U/L) 0 10 20 30 40 50 60 70 80 90 100 Screening Day 1 Dosing Day 7 Unsch. Day 13 Unsch. Day 16 Day 30 Day 42 Unsch. Day 53 Unsch. Day 64 Unsch. Day 78 Day 90 Day 120 Day 180 Day 240 Day 300 Day 360 AST (U/L) AST (U/L) Participant 2 Participant 3 Participant 4 Participant 5 Participant 2 Participant 3 Participant 4 Participant 5 PBFT02 PBFT02 ITR ITR CB7 promoter Chimeric intron Codon ŽƉƟŵŝnjĞĚ​ŚGRN PolyA &ŝŐƵƌĞ​ϭ​ʹ​​W&dϬϮ​ǀĞĐƚŽƌ​ƐƚƌƵĐƚƵƌĞ &ŝŐƵƌĞ​ϰ​W'ZE​ůĞǀĞůƐ​ŝŶ​&​ĨŽůůŽǁŝŶŐ​W&dϬϮ​ ĂĚŵŝŶŝƐƚƌĂƟŽŶ DĞĚŝĐĂů​ǁƌŝƟŶŐ​ƐƵƉƉŽƌƚ​ǁĂƐ​ƉƌŽǀŝĚĞĚ​ďLJ​ WĂƌĞdžĞů​/ŶƚĞƌŶĂƟŽŶĂů​ĂŶĚ​ĨƵŶĚĞĚ​ďLJ​WĂƐƐĂŐĞ​ŝŽ͕​/ŶĐ​ • ƚƵĚŝĞƐ​ŝŶ​ŶŽŶͲŚƵŵĂŶ​ƉƌŝŵĂƚĞƐ​ŚĂǀĞ​ ĚĞŵŽŶƐƚƌĂƚĞĚ​ǁŝĚĞƐƉƌĞĂĚ​ĚŝƐƚƌŝďƵƟŽŶ​ŽĨ​ W&dϬϮ​ƚŚƌŽƵŐŚŽƵƚ​ƚŚĞ​ďƌĂŝŶ​ǁŚĞŶ​ĂĚŵŝŶŝƐƚĞƌĞĚ​ ŝŶƚƌĂƚŚĞĐĂůůLJ​ŝŶ​ƚŚĞ​ĐŝƐƚĞƌŶĂ​ŵĂŐŶĂϭ • /Ŷ​ŵƵƌŝŶĞ​ŵŽĚĞůƐ​ŽĨ​&d͕​ĂĚŵŝŶŝƐƚƌĂƟŽŶ​ŽĨ​ W&dϬϮ​ƌĞƐƚŽƌĞƐ​ůLJƐŽƐŽŵĂů​ĨƵŶĐƟŽŶ​ĂŶĚ​ƌĞĚƵĐĞƐ​ ŶĞƵƌŽĚĞŐĞŶĞƌĂƟŽŶϭ • W&dϬϮ​ŝƐ​ďĞŝŶŐ​ĚĞǀĞůŽƉĞĚ​ĂƐ​Ă​ĚŝƐĞĂƐĞͲŵŽĚŝĨLJŝŶŐ​ ƚŚĞƌĂƉLJ​ĨŽƌ​ŝŶĚŝǀŝĚƵĂůƐ​ǁŝƚŚ​&dͲGRN and &dͲC9orf72 • ,ĞƌĞ​ǁĞ​ƉƌĞƐĞŶƚ​ŝŶƚĞƌŝŵ​ƐĂĨĞƚLJ​ĂŶĚ​ďŝŽŵĂƌŬĞƌ​ ĚĂƚĂ​ĨƌŽŵ​&dͲGRN​ƉĂƌƟĐŝƉĂŶƚƐ​ŝŶ​ƵƉůŝ&dͲ​ ŽŚŽƌƚ​ϭ Methods ƚƵĚLJ​ĚĞƐŝŐŶ • W&dϬϮ​ŝƐ​ďĞŝŶŐ​ĂƐƐĞƐƐĞĚ​ŝŶ​Ă​ƉŚĂƐĞ​ϭͬϮ​ ĐůŝŶŝĐĂů​ƚƌŝĂů​ŝŶ​ƉĂƌƟĐŝƉĂŶƚƐ​ǁŝƚŚ​&dͲGRN and &dͲC9orf72​;ƵƉůŝ&dͲ͖​EdϬϰϳϰϳϰϯϭͿ​;&ŝŐƵƌĞ​ϮͿ • dŚŝƐ​ŵƵůƟͲĐĞŶƚĞƌ͕​ŽƉĞŶͲůĂďĞů͕​ĮƌƐƚͲŝŶͲŚƵŵĂŶ​ƐƚƵĚLJ​ ǁĂƐ​ĚĞƐŝŐŶĞĚ​ƚŽ​ĞǀĂůƵĂƚĞ​ƐĂĨĞƚLJ͕​ƚŽůĞƌĂďŝůŝƚLJ͕​ĂŶĚ​ ƉŚĂƌŵĂĐŽĚLJŶĂŵŝĐƐ​ŽĨ​W&dϬϮ • ĚĚŝƟŽŶĂů​ĞŶĚƉŽŝŶƚƐ​ŝŶĐůƵĚĞ͕​ďŝŽŵĂƌŬĞƌƐ​ŽĨ​ ůLJƐŽƐŽŵĂů​ĚLJƐĨƵŶĐƟŽŶ​ĂŶĚ​ŶĞƵƌŽĚĞŐĞŶĞƌĂƟŽŶ͕​ ŝŵŵƵŶŽŐĞŶŝĐŝƚLJ͕​ĂŶĚ​ĐůŝŶŝĐĂů​ƐƚĂƚƵƐ • W&dϬϮ​ŝƐ​ĂĚŵŝŶŝƐƚĞƌĞĚ​ǀŝĂ​/D​ŝŶũĞĐƟŽŶ​ƵŶĚĞƌ​ d​ŐƵŝĚĂŶĐĞ &ŝŐƵƌĞ​Ϯ​ƵƉůŝ&dͲ​ƐƚƵĚLJ​ĚĞƐŝŐŶ FTD-GRN COHORT 2 Dose 1 (3.3e10 GC/g*) COHORT 3 ;KƉƟŽŶĂůͿ COHORT 4 COHORT 5 FTD-C9orf72 COHORT 1 Dose 1 (3.3e10 GC/g*) Completed IDMC review Ύ'ͬŐ͕​ŐĞŶĞ​ĐŽƉŝĞƐ​ƉĞƌ​ŐƌĂŵ​ŽĨ​ĞƐƟŵĂƚĞĚ​ďƌĂŝŶ​ǁĞŝŐŚƚ ĂƐŚĞĚ​ůŝŶĞƐ​ƌĞƉƌĞƐĞŶƚ​ŽďƐĞƌǀĞĚ​ƌĂŶŐĞ​ŽĨ​W'ZE​ůĞǀĞůƐ​ŝŶ​&​ĨƌŽŵ​ŚĞĂůƚŚLJ​ĂĚƵůƚƐ​ ;ϯ͘Ϯϴʹϴ͘ϭϱ​ŶŐͬŵ>͕​ŶсϲϭͿ ƚƵĚLJ​ƐƚĂƚƵƐ • &ŝǀĞ​ƉĂƌƟĐŝƉĂŶƚƐ​ǁĞƌĞ​ĞŶƌŽůůĞĚ​ŝŶ​ŽŚŽƌƚ​ϭ͖​ ĨŽƵƌ​ƉĂƌƟĐŝƉĂŶƚƐ​ƌĞŵĂŝŶ​ŝŶ​ƚŚĞ​ƐƚƵĚLJ​ĂƐ​ŽĨ​ ƵŐƵƐƚ​ϮϬ͕​ϮϬϮϰ​;ŵŽƐƚ​ƌĞĐĞŶƚ​ĚĂƚĂ​ĐƵƚͿ • KŶĞ​ƉĂƌƟĐŝƉĂŶƚ​ǁŝƚŚĚƌĞǁ​ĨƌŽŵ​ƚŚĞ​ƐƚƵĚLJ​ ϯ​ŵŽŶƚŚƐ​ƉŽƐƚͲW&dϬϮ​ĂĚŵŝŶŝƐƚƌĂƟŽŶ • ŽŚŽƌƚ​Ϯ​ŝƐ​ĐƵƌƌĞŶƚůLJ​ĞŶƌŽůůŝŶŐ • ŽŚŽƌƚ​ϰ​ŝƐ​ĂŶƟĐŝƉĂƚĞĚ​ƚŽ​ďĞ​ŽƉĞŶ​ĨŽƌ​ĞŶƌŽůůŵĞŶƚ​ ŝŶ​ƚŚĞ​ĮƌƐƚ​ŚĂůĨ​ŽĨ​ϮϬϮϱ ZĞĨĞƌĞŶĐĞ͗​ϭ͗​ĂƚĂ​ŽŶ​ĨŝůĞ /ŵŵƵŶŽŐĞŶŝĐŝƚLJ • EŽŶĞ​ŽĨ​ƚŚĞ​ƉĂƌƟĐŝƉĂŶƚƐ​ŝŶ​ŽŚŽƌƚ​ϭ​ŚĂĚ​ĂŶƟͲsϭ​ŶĞƵƚƌĂůŝnjŝŶŐ​ĂŶƟďŽĚŝĞƐ​Ăƚ​ďĂƐĞůŝŶĞ͖​ ĂƐ​ĞdžƉĞĐƚĞĚ͕​Ăůů​ƉĂƌƟĐŝƉĂŶƚƐ​ĚĞǀĞůŽƉĞĚ​ĂŶƟͲsϭ​ĂŶƟďŽĚŝĞƐ​ŝŶ​&​ĂŶĚ​ƐĞƌƵŵ​Ăƚ​ ϯϬ​ĚĂLJƐ​ƉŽƐƚͲW&dϬϮ​ƚƌĞĂƚŵĞŶƚ​ • dǁŽ​ƉĂƌƟĐŝƉĂŶƚƐ​ĚĞǀĞůŽƉĞĚ​dͲĐĞůů​ƌĞƐƉŽŶƐĞ​ĂŐĂŝŶƐƚ​sϭ​ϭϴϬ​ĚĂLJƐ​ƉŽƐƚͲW&dϬϮ​ ƚƌĞĂƚŵĞŶƚ͕​ǁŝƚŚ​ŶŽ​ĐůŝŶŝĐĂů​ƐŝŐŶŝĮĐĂŶĐĞ • EŽ​dͲ​Žƌ​ͲĐĞůů​ŝŵŵƵŶĞ​ƌĞƐƉŽŶƐĞ​ĂŐĂŝŶƐƚ​ŚW'ZE​ǁĂƐ​ĚĞƚĞĐƚĞĚ ​ƐŝŶŐůĞ​ĚŽƐĞ​ŽĨ​W&dϬϮ​ƉƌŽŵŽƚĞƐ​Ă​ƌŽďƵƐƚ​ĂŶĚ​ ĚƵƌĂďůĞ​ŝŶĐƌĞĂƐĞ​ŝŶ​W'ZE​ĞdžƉƌĞƐƐŝŽŶ • ZĞůĂƟǀĞ​ƚŽ​ďĂƐĞůŝŶĞ͕​W&dϬϮ​ŝŶĐƌĞĂƐĞĚ​&​W'ZE​ ĞdžƉƌĞƐƐŝŽŶ​ŝŶ​Ăůů​ƉĂƌƟĐŝƉĂŶƚƐ͖​ƵƉ​ƚŽ​ϲͲĨŽůĚ​Ăƚ​ĚĂLJ​ϯϬ​ ;ŶсϱͿ​ĂŶĚ​ƵƉ​ƚŽ​ϭϬͲĨŽůĚ​Ăƚ​ĚĂLJ​ϭϴϬ​;ŶсϮͿ͘​dŚĞ​ĞīĞĐƚ​ŽĨ​ W&dϬϮ​ǁĂƐ​ĐŽŶƐŝƐƚĞŶƚ​ĂĐƌŽƐƐ​Ăůů​ƉĂƌƟĐŝƉĂŶƚƐ​;&ŝŐƵƌĞ​ϰͿ • &​W'ZE​ůĞǀĞůƐ​ƌĞŵĂŝŶĞĚ​ĞůĞǀĂƚĞĚ​Ăƚ​ĚĂLJ​ϯϲϬ​;ŶсϭͿ͘​ dŚĞ​ƌĂƚĞ​ŽĨ​ŝŶĐƌĞĂƐĞ​ƐůŽǁĞĚ​ďĞƚǁĞĞŶ​ĚĂLJƐ​ϭϴϬ​ĂŶĚ​ϯϲϬ​ ;ϯϬͲϭϴϬ͗​ϱϴй​ǀƐ͘​ϭϴϬͲϯϲϬ͗​ϮϲйͿ • &ŽůůŽǁŝŶŐ​W&dϬϮ​ƚƌĞĂƚŵĞŶƚ͕​ƉůĂƐŵĂ​W'ZE​ĞdžƉƌĞƐƐŝŽŶ​ ƌĞŵĂŝŶĞĚ​ďĞůŽǁ​ƚŚĞ​ƌĂŶŐĞ​ŽďƐĞƌǀĞĚ​ŝŶ​ŚĞĂůƚŚLJ​ĂĚƵůƚƐ​ ĂŵŽŶŐ​Ăůů​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ​ &ŝŐƵƌĞ​ϯ ,ĞƉĂƚŽƚŽdžŝĐŝƚLJ​ŵĂƌŬĞƌƐ​ƉŽƐƚͲW&dϬϮ​ĂĚŵŝŶŝƐƚƌĂƟŽŶ​ŝŶ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ​ ǁŚŽ​ƌĞĐĞŝǀĞĚ​Ă​ƌĞǀŝƐĞĚ​ŝŵŵƵŶŽƐƵƉƉƌĞƐƐŝŽŶ​ƌĞŐŝŵĞŶ​ ĂƐĞůŝŶĞ​ĚĞŵŽŐƌĂƉŚŝĐƐ​ĂŶĚ​ĐůŝŶŝĐĂů​ĐŚĂƌĂĐƚĞƌŝƐƟĐƐ • ĂƐĞůŝŶĞ​ĚĞŵŽŐƌĂƉŚŝĐƐ​ĂŶĚ​ĐůŝŶŝĐĂů​ĐŚĂƌĂĐƚĞƌŝƐƟĐƐ​ŽĨ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ​ĂƌĞ​ƐŚŽǁŶ​ in Table 1 • ůů​ƉĂƌƟĐŝƉĂŶƚƐ​ŚĂĚ​Ă​ĐŽŶĮƌŵĞĚ​ƉĂƚŚŽŐĞŶŝĐ​GRN​ŵƵƚĂƟŽŶ​ĂŶĚ​ƐLJŵƉƚŽŵĂƟĐ​&dͲGRN ;Z͕​Ƶŵ​ŽĨ​ŽdžĞƐ​ƐĐŽƌĞƐ​ƌĂŶŐĞĚ​ďĞƚǁĞĞŶ​ϳ​ĂŶĚ​ϭϳͿ ĂLJ​ϭ ĂLJ​ϯϬ ĂLJ​ϲϬ​ ĂLJ​ϭϴϬ ĂLJ​ϯϲϬ Wϭ ϭ͘ϵ ϭϮ͘ϳ Eͬ Eͬ Eͬ WϮ Ϯ͘ϴ ϭϳ͘ϯ Eͬ Ϯϳ͘ϯ ϯϰ͘Ϭ Wϯ Ϯ͘ϵ ϭϬ͘ϳ ϭϯ͘ϳ Ϯϭ͘ϳ Eͬ Wϰ Ϯ͘Ϯ ϭϮ͘ϯ Eͬ Eͬ Eͬ Wϱ Ϯ͘ϯ ϭϯ͘ϲ Eͬ Eͬ Eͬ Table 2 ĚǀĞƌƐĞ​ĞǀĞŶƚƐ​ƌĞƉŽƌƚĞĚ​ĂŵŽŶŐ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ ŽŚŽƌƚ​ϭ​;EсϱͿ͕​Ŷ​;йͿ​΀ĞǀĞŶƚƐ΁ ŶLJ​ƚƌĞĂƚŵĞŶƚͲƌĞůĂƚĞĚ​d ϱ​;ϭϬϬ͘ϬͿ​΀ϰϬ΁ DŝůĚ​;'ƌĂĚĞ​ϭͿ ϱ​;ϭϬϬ͘ϬͿ​΀Ϯϵ΁ DŽĚĞƌĂƚĞ​;'ƌĂĚĞ​ϮͿ ϰ​;ϴϬ͘ϬͿ​΀ϵ΁ ĞǀĞƌĞ​;'ƌĂĚĞ​ϯͿ ϭ​;ϮϬ͘ϬͿ΀Ϯ΁ >ŝĨĞ​ƚŚƌĞĂƚĞŶŝŶŐ​;'ƌĂĚĞ​ϰͿ Ϭ​ ĞĂƚŚ​;'ƌĂĚĞ​ϱͿ Ϭ ŶLJ​ ϭ​;ϮϬ͘ϬͿ​΀Ϯ΁ ŶLJ​ƚƌĞĂƚŵĞŶƚͲƌĞůĂƚĞĚ​ ϭ​;ϮϬ͘ϬͿ​΀Ϯ΁ ŶLJ​d​ůĞĂĚŝŶŐ​ƚŽ​ĞĂƌůLJ​ĚŝƐĐŽŶƟŶƵĂƟŽŶ ϭ​;ϮϬ͘ϬͿ DŽƐƚ​ĐŽŵŵŽŶ​d​ďLJ​K​ĂŵŽŶŐ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ​ǁĂƐ​ŶĞƌǀŽƵƐ​ƐLJƐƚĞŵ​ĚŝƐŽƌĚĞƌƐ​;Ŷсϰ͖​ϴϬ͘ϬйͿ͘​Ɛ​ŝŶĐůƵĚĞĚ​ŚĞƉĂƚŽƚŽdžŝĐŝƚLJ​ ĂŶĚ​ĐĞƌĞďƌĂů​ǀĞŶŽƵƐ​ƐŝŶƵƐ​ƚŚƌŽŵďŽƐŝƐ​;ĂƐLJŵƉƚŽŵĂƟĐ​ĂŶĚ​ĚĞƚĞĐƚĞĚ​ŽŶ​ĂŶ​ƵŶƐĐŚĞĚƵůĞĚ​DZ/​ƐĐĂŶ​ϱϱ​ĚĂLJƐ​ƉŽƐƚͲƚƌĞĂƚŵĞŶƚͿ͖​ďŽƚŚ​ǁĞƌĞ​ ĐŽŶƐŝĚĞƌĞĚ​ƚƌĞĂƚŵĞŶƚͲ​Žƌ​ƉƌŽĐĞĚƵƌĞͲƌĞůĂƚĞĚ Table 1 ĂƐĞůŝŶĞ​ĚĞŵŽŐƌĂƉŚŝĐƐ​ĂŶĚ​ĐůŝŶŝĐĂů​ĐŚĂƌĂĐƚĞƌŝƐƟĐƐ​ŽĨ​ŽŚŽƌƚ​ϭ​ƉĂƌƟĐŝƉĂŶƚƐ P1 P2 Wϯ Wϰ P5 ŐĞ​;LJĞĂƌƐͿ ϱϭ ϱϵ ϲϬ ϲϵ ϳϭ 'ĞŶĚĞƌ Male &ĞŵĂůĞ Male Male &ĞŵĂůĞ &dͲGRN​ƉŚĞŶŽƚLJƉĞ ůǀWW ďǀ&d ďǀ&d ƐǀWW ďǀ&d ŐĞ​Ăƚ​ĚŝĂŐŶŽƐŝƐ​;ĚŝƐĞĂƐĞ​ĚƵƌĂƟŽŶ͕​LJĞĂƌƐͿ ϰϳ​;ϰͿ ϱϲ​;ϯͿ ϱϵ​;ϭͿ ϲϴ​;ϭͿ ϲϳ​;ϰͿ W'ZE​Ăƚ​ƐĐƌĞĞŶŝŶŐ͕​ƉůĂƐŵĂ​;ŶŐͬŵ>Ϳ ϲϬ͘ϵ ϰϰ͘ϴ ϯϲ͘Ϭ Ϯϱ͘ϱ ϭϳ͘ϰ W'ZE​Ăƚ​ďĂƐĞůŝŶĞ͕​&​;ŶŐͬŵ>Ϳ ϭ͘ϵ Ϯ͘ϴ Ϯ͘ϵ Ϯ͘Ϯ Ϯ͘ϯ ůŝŶŝĐĂů​ĞŵĞŶƟĂ​ZĂƟŶŐ​ĐĂůĞ͕​'ůŽďĂů ϭ Ϯ Ϯ Ϯ ϭ ůŝŶŝĐĂů​ĞŵĞŶƟĂ​ZĂƟŶŐ​ĐĂůĞ͕​Ƶŵ​ŽĨ​ŽdžĞƐ ϳ͘ϱ ϭϳ ϭϮ ϭϭ ϳ ůŝŶŝĐĂů​ĞŵĞŶƟĂ​ZĂƟŶŐ​ĐĂůĞ͕​Ƶŵ​ŽĨ​ŽdžĞƐ​ŚĂƐ​Ă​ƚŽƚĂů​ƐĐŽƌĞ​ŽĨ​Ϯϰ͖​ŚŝŐŚĞƌ​ƐĐŽƌĞƐ​ĂƌĞ​ŝŶĚŝĐĂƟǀĞ​ŽĨ​ŵŽƌĞ​ƐĞǀĞƌĞ​ĚĞŵĞŶƟĂ​ƉŚĞŶŽƚLJƉĞƐ Poster No. 007 ŽƉŝĞƐ​ŽĨ​ƚŚŝƐ​ƉŽƐƚĞƌ​ƉƌĞƐĞŶƚĂƚŝŽŶ​ŽďƚĂŝŶĞĚ​ƚŚƌŽƵŐŚ​YƵŝĐŬ​ZĞƐƉŽŶƐĞ​ ;YZͿ​ŽĚĞ​ĂƌĞ​ĨŽƌ​ƉĞƌƐŽŶĂů​ƵƐĞ​ŽŶůLJ​ĂŶĚ​ŵĂLJ​ŶŽƚ​ďĞ​ƌĞƉƌŽĚƵĐĞĚ​ ǁŝƚŚŽƵƚ​ƉĞƌŵŝƐƐŝŽŶ​ŽĨ​WĂƐƐĂŐĞ​ŝŽ͕​/ŶĐ͘ ŚƚƚƉƐ͗ͬͬďŝƚ͘ůLJͬϯyŬsďϴŚ