Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

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Registration Statement (Form S-8 No. 333-231618) of Applied Therapeutics, Inc., pertaining to the 2016 Equity Incentive Plan, as Amended, the 2019 Equity Incentive Plan, and the 2019 Employee Stock Purchase Plan;

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Registration Statement (Form S-8 No. 333-255018) of Applied Therapeutics, Inc., pertaining to the 2019 Equity Incentive Plan;

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Registration Statement (Form S-8 No. 333-270767) of Applied Therapeutics, Inc., pertaining to the 2019 Equity Incentive Plan; and

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Registration Statement (Form S-3 No. 333-271887) of Applied Therapeutics, Inc.

of our report dated March 6, 2024, with respect to the financial statements of Applied Therapeutics, Inc. included in this Annual Report (Form 10-K) of Applied Therapeutics for the year ended December 31, 2023.

6, 2023

/s/ Ernst & Young LLP

New York, New York

March 6, 2024