EXHIBIT 32.1

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Certification of Chief Executive Officer Pursuant to 18 U.S.C. Section 1350

(as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002)

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In connection with the Quarterly Report on Form 10-Q for the quarter ended June 30, 2021 (the “Periodic Report”), I, Daniel R. Sheehan, Chief Executive Officer of Professional Holding Corp. (the “Company”) hereby certify that:

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1.    The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934; and

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2.    The information contained in the Periodic Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

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