Corporate PresentationAugust 2024 Exhibit 99.2

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Well Positioned with Multiple Near-Term Clinical Catalysts Precision Therapy Platform Developing a novel class of drugs called virus-like drug conjugates (VDCs) Direct tumor cell killing and immune activation Focal treatment approach to deliver durable response Large Market Opportunity In Areas of Unmet Need Ocular Oncology >60,000 patients/yr (US/EU)2 Urologic Oncology ~500,000 patients/yr (globally)3 Key Upcoming Catalysts Multiple clinical data readouts expected within next 6-12 months, including early Phase 1 bladder data Cash expected to fund operations into 2H 2026 Late-Stage Clinical Development Phase 3 in Primary Uveal Melanoma Ongoing FDA SPA1 Agreement 1. Special Protocol Assessment (SPA). 2. See sources on slide 9 of this presentation. 3. Bladder cancer. Putnam & Assoc. Epidemiology Analysis.

Clinical Pipeline Across Multiple Solid Tumor Indications Program OTHER SOLID TUMORS OCULAR ONCOLOGY Preclinical Phase 1 Phase 2 Phase 3 Planned Milestones Metastases to the Choroid (Multiple primary cancers with metastasis to the choroid, e.g., Breast and Lung) Primary Uveal Melanoma Ocular Surface Cancers Bladder Cancer (Non-Muscle Invasive (NMIBC) and Muscle Invasive (MIBC)) Other HSPG* Expressing Tumors 2024 – Phase 2 initiation YE 2024 – Initial Phase 2 data October 2024 – Early Phase 1 NMIBC data 2024 – Phase 3 enrollment ongoing September 2024 – Phase 2 end of study data *Virus-like drug conjugates (VDCs) bind to a subset of modified tumor associated glycosaminoglycans (GAGs) that are part of the heparan sulphate chain of heparan sulfate proteoglycans (HSPGs). Schiller et al. Viruses 2022, 14(8), 1656

Bel-sar is a Potential First-in-Class Therapy for Multiple Solid Tumors

Bel-sar (AU-011) is a VDC Designed with Dual Specificity to Reduce Potential for Off-target Effects: Selectively binds totumor cells (not tolocal healthy tissue) Activated only at site of laser administration Fleury MJJ et al. Mol Biotechnol. 2014;56(5):479-86. Kines RC, et al. Int J Cancer. 2016;138(4):901–11. Kines RC, et al. Mol Cancer Ther. 2018;17(2):565–74. Kines RC, et al. Cancer Immunol Res. 2021;9:693–706. HPV, human papillomavirus; mHSPG, modified heparan sulphate proteoglycan; NIR, near infrared; VDC, virus-like drug conjugate; VLP, virus-like particle. Bel-sar (AU-011) VDCs selectively deliver direct tumor cell killing and immune activation Virus-like particle (VLP) Non-replicating viral capsid (no genetic material) Derived from HPV Multivalent binding to mHSPGs on solid tumor cells Light-activatable molecules VLP conjugated to ~200 molecules of phthalocyanine dye Activated by standardNIR laser Virus-like drug conjugates (VDCs) are a novel technology platform 6

Disruption of the tumorcell membrane andpro-immunogenic cell deathby necrosis leads to T cell activation and immune-mediated tumor cell killing Bel-sar is a VDC with a novel dual mechanismof action Kines RC, et al. Int J Cancer. 2016;138(4):901–11. Kines RC, et al. Mol Cancer Ther. 2018;17(2):565–74. Kines RC, et al. Cancer Immunol Res. 2021;9:693–706.DAMPs, damage-associated molecular patterns; HSPG, heparan sulfate proteoglycan; VDC, virus-like drug conjugate; VLP, virus-like particle. Bel-sar, AU-011 Reactive oxygen species disrupts cell membrane and organelles

Ocular Oncology Therapeutic Area Bel-sar Target Indications: Primary Uveal Melanoma Metastases to the Choroid Ocular Surface Cancers

Bel-sar Opportunities in Ocular Oncology Represent a Multi-billion-dollar Addressable Market Ocular Oncology Total Addressable Market (US/EU) ~66,000 patients/year Ocular Surface Cancers Retinoblastoma Primary Uveal Melanoma Metastases to the Choroid ~11,000 patients/year1 ~20,000 patients/year1 ~500 patients/year2 ~35,000 patients/year3 1. ClearView & Putnam & Assoc. Epidemiology Analysis Choroidal Melanoma and Choroidal Metastasis 2. American Cancer Society- Retinoblastoma statistics 3. Includes Conjunctival Melanoma, Primary Acquired Melanosis, Squamous Cell Carcinoma and Ocular Surface Squamous Neoplasia (https://pubmed.ncbi.nlm.nih.gov/12788119/; https://pubmed.ncbi.nlm.nih.gov/19628487/; https://pubmed.ncbi.nlm.nih.gov/8676629/; https://pubmed.ncbi.nlm.nih.gov/29511061/; https://pubmed.ncbi.nlm.nih.gov/9037556/) Bel-sar (AU-011) is an investigational product candidate. The effectiveness and safety of bel-sar have not been established, and bel-sar is not approved for use in any jurisdiction. ~80% of patients are diagnosed at the early stage (indeterminate lesions (ILs) and small tumors) Current radiotherapy treatment Leaves up to 87% of patients with major irreversible vision loss ~100 Ocular Oncologists in US/EU — focused call point opportunity <20 Field Based Team — Intend to add small sales force to launch globally

Primary Uveal Melanoma—High Unmet Medical Need Primary Uveal Melanoma is a Rare and Life-Threatening Ocular Cancer with No Drugs Approved 1. Heiting, G. Iris/uvea of the eye. Accessed Oct. 3, 2023. https://www.allaboutvision.com/en-gb/resources/uvea-iris-choroid/ 2. Kaliki S, Shields CL. Uveal melanoma: relatively rare but deadly cancer. Eye (Lond). 2017;31(2):241-257. doi:10.1038/eye.2016.275 3. Clearview & Putnam & Assoc. Market Research Most common primary intraocular cancer in adults2 Impacts ~11,000 patients in US/EU per year3 ~80% patients diagnosed with early-stage disease3 Choroid is 90% of the uvea1 50% of patients develop metastasis within 15 years (metastatic uveal melanoma)2 choroid Uvea: Choroid, Ciliary Body and Iris

Current Treatment Paradigm for Uveal Melanoma IndeterminateLesions Small Melanomas Risk Factors Growth Small CM Observation Incidence: Patients US/EU1 Local – Early (~8,000) Local – Late (~2,300) Metastatic (~2,000) SIZE (mm): Small Medium Large Metastatic Radiotherapy Radiotherapy 1 2.5–3 >10 Enuc. 1. Each figure represents ~250 persons. Shields CL et al. Choroidal and ciliary body melanoma. Available at: https://eyewiki.aao.org/Choroidal_and_Ciliary_Body_Melanoma. Accessed May 2, 2024. Epidemiology analysis for choroidal melanoma and choroidal metastasis by ClearView Healthcare Partners and Putman. Enuc., enucleation. CM, Choroidal Melanoma. Systemic Chemotherapy (KIMMTRAK®)

High Morbidity Associated with Current Standard of Care 1. Jarczak J, Karska-Basta I, Romanowska-Dixon B. Deterioration of visual acuity after brachytherapy and proton therapy of uveal melanoma, and methods of counteracting this complication based on recent publications. Medicina (Kaunas). 2023;59(6):1131. 2. Tsui I, Beardsley RM, McCannel TA, Oliver SC, et al. Visual acuity, contrast sensitivity and color vision three years after iodine-125 brachytherapy for choroidal and ciliary body melanoma. Open Ophthalmol J. 2015;9:131-5. 3. Shields CL et al. Arch Ophthalmol. 2000;118(9):1219-1228. 4. Peddada KV et al. J Contemp Brachytherapy. 2019;11(4):392-397. 5. Jarczak J et al. Medicina (Kaunas). 2023;59(6):1131. 6. Shields CL et al. Curr Opin Ophthalmol. 2019;30(3):206-214. 7. Kaliki S, Shields CL. Eye 2017;31(2):241-257. AE, adverse event; BCVA, best-corrected visual acuity; HRVL, high-risk for vision loss. Up to 87% of Primary Uveal Melanoma Patients Become Legally Blind Over Time in the Eye Treated with Radiotherapy1,2 Radiotherapy3–7 Adverse Event Surgeries secondary to AEs (e.g., cataracts) 40%+ Radiation retinopathy 40%+ Neovascular glaucoma 10% Dry eye syndrome 20% Strabismus 2%+ Retinal detachment 1-2% Vision loss (≥15 letters) ~70% Long-term legal blindness (≤20/200) ~90% Serious Adverse Event Scleral necrosis 0-5% Enucleation/eye loss 10-15% Severe vision loss (≥30 letters) in HRVL ~90%

c Bel-sar has the Potential to be the First Approved Therapy in Primary Uveal Melanoma No radiation-related morbidity Preservation of vision Local tumor control Opportunity to treat early and reduce risk of metastases Improvement in safety and quality of life Bel-sar is Delivered by Simple Suprachoroidal Injection Goals of Treatment Light Activation with Standard Ophthalmic Laser In-Office Procedure Two ~2 minuteInjections Two ~5 minute Lasers Bel-sar (AU-011) is an investigational product candidate. The effectiveness and safety of bel-sar have not been established, and bel-sar is not approved for use in any jurisdiction.

Phase 2 Trial – Dose Escalation and Expansion with Suprachoroidal Administration Patient Population Representative of Early-Stage Disease: Small Choroidal Melanoma and Indeterminate Lesions Trial Design – Enrollment Complete (n=22) One Cycle = Doses on days 1, 8 and 15 N=10 1- 2 Doses (n=9); 2 cycles-6 doses (n=1) N=11** 3 Cycles (9 doses) 1 dose- 20 μg x 1 Laser 1 dose- 40 μg x 1 Laser 1 dose- 40 μg x 2 Lasers 2 doses- 40 μg x 2 Lasers QWx2 Cohort 1 (n=1) Cohort 2 (n=3*) Cohort 3 (n=2) Cohort 4 (n=3) Cohort 5 9 doses- 80 μg x 2 Lasers QWx3 3 cycles Cohort 6 (n=up to 10) 2 Cycles (n=1) 3 Cycles (n=2) 6-9 doses- 40 μg x 2 Lasers QWx3 Up to 3 cycles Subtherapeutic Regimens Therapeutic Regimen Goal: To Determine Safety, Optimal Dose and Therapeutic Regimen with Suprachoroidal Administration Endpoint Endpoint Definitions Tumor Progression Growth in Tumor Height ≥0.5mm or ≥1.5 mm in Largest Basal Diameter (LBD) Visual Acuity Loss Decrease from Baseline: ≥15 letters Tumor Thickness Growth Rate Change in Rate of Growth of Tumor Thickness *Cohort 2: 2 subjects were planned; third subject was additionally enrolled due to dose error in 1 subject **12 patients enrolled, 1 subject who discontinued after 1 cycle due to unrelated SAEs is not included in data analysis (n=11). ClinicalTrials.gov Identifier: NCT04417530 ; AU-011-202

Phase 2 Interim Data Demonstrates Tumor Control, Vision Preservation and a Favorable Safety Profile Subtherapeutic Therapeutic Tumor Progression: change from baseline in thickness ≥0.5mm; or in LBD ≥1.5mm confirmed by at least one repeat assessment August 3, 2023, data on file Aura Biosciences Vision acuity loss definition based on ETDRS BCVA letter score (≥ 15 letters from baseline) Median Change in BCVA in Phase 3 Eligible Patients with Therapeutic Regimen (n=10) Months 80% Tumor Control Rate 90% Visual Acuity Preservation Rate <20% Grade 1 AEs Vision Loss (15 letters)

SPA Agreement with FDA Supports Global Phase 3 Trial DesignFast Track and Orphan Drug Designations Time to Composite Endpoint: Tumor Progression or Visual Acuity Failure Time to Tumor Progression Primary Endpoint First Key Secondary Endpoint Enrollment (N=~100) Randomize (2:1:2) 80 µg bel-sar treatment arm (n=40) 40 µg bel-sar treatment arm (n=20) Sham control arm (n=40) 15 Month Primary Efficacy Analysis An SPA Indicates Concurrence by the FDA that the Design of the Trial can Adequately Support a Regulatory Submission SPA Agreement SPA – Special Protocol Assessment

Kaplan-Meier analysis simulation of Phase 2 interim data support assumptions for the potential success of Phase 3 trial with high statistical significance Progression-free probability Days Progression-free probability Log-rank test P = 0.0012 Log-rank test P = 0.0023 Time to tumor progression Time to composite endpoint Change from baseline in thickness ≥0.5 mm or in LBD ≥1.5 mm confirmed by at least one repeat assessment 3 cycles, n=10 Subtherapeutic (≤2 cycles), n=10 Time to tumor progression or vision acuity failure (≥15 letter loss in ETDRS-BCVA), whichever occurs earlier 0.0 0.2 0.4 0.6 0.8 1.0 0 100 200 300 400 500 0.0 0.2 0.4 0.6 0.8 1.0 0 100 200 300 400 500 + Censored + Censored Study duration 12 months. Participants either had an event or were censored at the last visit; some had their Week 52 visit after 365 days. Any events at the final visit are assigned to the actual time of that visit. Log-rank test p-value based on unsimulated original Kaplan-Meier curves. BCVA, best-corrected visual acuity; ETDRS, Early Treatment Diabetic Retinopathy Study; LBD, largest basal diameter. August 3, 2023 data on file, Aura Biosciences. ClinicalTrials.gov Identifier: NCT04417530; AU-011-202.

Phase 3 trial design P < 0.005 93% power (Δ20) Actual data (Δ60) >99% power P < 0.05 Robustness Analysis of Phase 2 interim tumor control rates Overall rate in Phase 2 2x “worse” than Phase 2 2x “worse” than Phase 2 Actual rate with documented growth in Phase 2 Overall rate in Phase 2 94% power (Δ30) Actual data (Δ60) >99% power Same dose, regimen, route of administration, range of tumor sizes and reading center as Phase 2 trial Similar population to Phase 2 participants receiving the therapeutic regimen Enriching for early documented growth; Phase 3 randomization stratified by growth rate ClinicalTrials.gov Identifier: NCT06007690; AU-011-301. Phase 2 Interim Data Support Phase 3 Assumptions

Bel-sar Opportunities in Ocular Oncology Represent a Multi-billion-dollar Addressable Market Ocular Oncology Total Addressable Market (US/EU) ~66,000 patients/year Ocular Surface Cancers Retinoblastoma Primary Uveal Melanoma Metastases to the Choroid ~11,000 patients/year1 ~20,000 patients/year1 ~500 patients/year2 ~35,000 patients/year3 1. ClearView & Putnam & Assoc. Epidemiology Analysis Choroidal Melanoma and Choroidal Metastasis 2. American Cancer Society- Retinoblastoma statistics 3. Includes Conjunctival Melanoma, Primary Acquired Melanosis, Squamous Cell Carcinoma and Ocular Surface Squamous Neoplasia (https://pubmed.ncbi.nlm.nih.gov/12788119/; https://pubmed.ncbi.nlm.nih.gov/19628487/; https://pubmed.ncbi.nlm.nih.gov/8676629/; https://pubmed.ncbi.nlm.nih.gov/29511061/; https://pubmed.ncbi.nlm.nih.gov/9037556/) Bel-sar (AU-011) is an investigational product candidate. The effectiveness and safety of bel-sar have not been established, and bel-sar is not approved for use in any jurisdiction. Majority originate from breast and lung cancer Burdensome Standard of Care with Radiation Morbidities Daily treatments of radiotherapy for 4 weeks ~100 Ocular Oncologists in US/EU — focused call point opportunity <20 Field Based Team — Intend to add small sales force to launch globally

Metastases to the Choroid – Phase 2 Trial Expected to Begin in 2024 Cohort 1 N=3 patients 80µg 1 cycle Cohort 2 N=3 patients 160µg 1 cycle Cohort 3 N=3 patients 200µg 1 cycle Cohort 4 N=3 patients 200µg 2 cycles Safety/Dose-limiting Toxicity Efficacy Change in Tumor Size Change in Vision Letter Score Study Objectives Study Population Patients with Unilateral, Unifocal Metastases to the Choroid Breast or Lung Primary No Changes in Concurrent Systemic Medications Planned Planned Study Design (n=12*) Highlights: Primary Endpoint at One-month Post-treatment; Possibility to See Tumor Shrinkage and Vision Improvement *3+3 Design. Each cohort to have a minimum of 3 and a maximum of 6 patients.

Urologic Oncology Therapeutic Area Bel-sar Target Indications: Non-muscle invasive bladder cancer Muscle invasive bladder cancer

Bladder Cancer is a Global High Unmet Medical Need ~500,000 New cases/ year globally1 >200,000 NMIBC New cases/year US, Europe & Asia1 New cases/year US, Europe & Asia1 >60,000 MIBC Non-Muscle Invasive Bladder Cancer Muscle Invasive Bladder Cancer Recurrence, multiple TURBT surgeries, Progression of Disease, Loss of Bladder/Cystectomy Progression of Disease, Loss of Bladder/Cystectomy, Metastasis and Survival Unmet Need Unmet Need Bladder cancer. Putnam & Assoc. Epidemiology Analysis.

Current Treatment Paradigm for Non-Muscle Invasive Bladder Cancer Prevalence Patients (US)1,2 (~80,000) (~20,000) Progression Low grade – Low & intermediate risk High risk papillary disease CIS – BCG unresponsive BCG >6 tx Intravesical Chemotherapy (~4,000) TURBT recurrence Intravesical gene therapy (Adstiladrin®) Systemic immunotherapy (Keytruda®) Cystectomy TURBT recurrence High risk adjuvant therapy Adjuvant therapy Intravesical immunotherapy (Anktiva®) Each figure represents 1000 persons. Holzbeierlein JM et al. J Urol. 2024 Apr 25:101097JU0000000000003981 [epub ahead of print]. Holzbeierlein JM et al. J Urol. 2024 Apr;211(4):533-538. Internal Aura epidemiology of market size data on file.BCG, Bacillus Calmette-Guérin; TURBT, transurethral resection of the bladder. BCG >6 tx Intravesical Chemotherapy Intermediate risk adjuvant therapy

Bel-sar as Potential Front-Line Therapy in NMIBC may beOptimized for In Office-based Procedure Goals of Treatment with Bel-sar Reduce Risk of Recurrence Stimulate Anti-tumor Specific T Cell Response Focal Treatment with Direct Tumor Cell Killing Avoid TURBT /Operating Room No Virus Replication or Viral Shedding Lasers and Bladder Injections (e.g. Botox) are Commonly Used Bel-sar’s Local Administration Aligned with Current Urologic Oncology Practice Bel-sar has a Dual Mechanism of Action and its Local Administration is Aligned with Clinical Practice

Phase 1 trial for bladder cancer designed to evaluate safety, feasibility and MoA 21 participants Bel-sar alone Bel-sar + focal light activation Part 1 (n=5) Part 2 (n=16) Study objectives TURBT and cystectomy patients NMIBC and MIBC patients Safety & dose-limiting toxicity Focal distribution of bel-sar Feasibility of technique Focal necrosis Markers of immune activation Completed Ongoing No treatment-related AEs, SAEs, or dose-limiting toxicities were seen in the 5 patients NMIBC n=10 MIBC n=6 AE, adverse event; MIBC, muscle invasive bladder cancer; MoA, mechanism of action; NMIBC, non–muscle invasive bladder cancer; SAE, serious adverse event; TURBT, transurethral resection of bladder tumor. Clinicaltrials.gov identifier: NCT05483868; AU-011-102.

Clinical Complete Response with Immune Activation after Single Dose Confirmed by Histopathology DAY 1 Biopsy TURBT Biopsy Day 1 Day 1 Day 2 Day 3-7 Bel-sar (AU-011) TURBT- transurethral resection of bladder tumor Day 9 Ph 1- Preliminary Data Light Activated Cohort (n=1) Day 1 Diagnostic biopsy shows non- invasive, low grade urothelial carcinoma Injection of Bel-sar (100ug) performed within tumor and below tumor (Aura present w/ Urologist) Day 2 Urologist performs Light activation with 689nm infrared light (50J/cm2) (~5 min duration) (Aura present w/ Urologist) Day 9 Urologist performs TURBT in area where tumor used to be present. Biopsy shows denuded urothelial mucosa, no cancer cells; focal ulcer and chronic inflammation (eosinophils/lymphocytes)

Clinical Complete Response with Immune Activation after Single Dose Confirmed by Histopathology in Part 2 First Patient Papillary urothelial carcinoma Pre-injection bladder biopsy demonstrating low-grade papillary urothelial carcinoma; non-invasive. Post-treatment TURBT demonstrating necrosis, inflammatory infiltrate, and no residual carcinoma. Circled region shows area of necrosis; arrow indicates edge of inflammatory infiltrate. Evidence of complete response by absence of tumor cells, as well as immune activation, after single dose treatment in first patient 7 days after bel-sar treatment Example of papillary carcinoma (Ta) H&E stain Necrosis Immune infiltrate H&E, hematoxylin and eosin; TURBT, transurethral resection of the bladder. Clinicaltrials.gov identifier: NCT05483868; AU-011-102.

Company Highlights Ocular Oncology Therapeutic Area Primary Uveal Melanoma – Global Phase 3 CoMpass Trial: Trial actively enrolling Special Protocol Assessment (SPA) Agreement with FDA Phase 3 assumptions supported by Phase 2 data Metastases to the Choroid – Phase 2 trial planned to initiate in 2024 Second ocular indication potentially doubles market opportunity1 Initial data expected by year end 2024 Urologic Oncology Therapeutic Area Bladder Cancer – Phase 1 Trial Clinical complete response in first patient with single dose Company expects to present early non-muscle invasive bladder cancer data from ongoing Phase 1 trial at a urologic oncology investor event in October 2024 Corporate Strong cash position – expected to fund operations into 2H 2026 Experienced leadership team across functions ClearView & Putnam & Assoc. Epidemiology Analysis Choroidal Melanoma and Choroidal Metastasis. Bel-sar (AU-011) is an investigational product candidate. The effectiveness and safety of bel-sar have not been established, and bel-sar is not approved for use in any jurisdiction.

Appendix: Phase 2 Primary Uveal Melanoma Trial – Interim Data

High Local Complete Response Rate at 12 months Follow-up* Dose/Regimen Total Patients (n) Total Patients (n) Tumor Control Rate Subtherapeutic Regimens Single dose up to 2 cycles 10 20% (2/10) Therapeutic Regimen 3 Cycles (n=11) 11 73% (8/11) 3 Cycles and Phase 3 eligible (n=10)* 10 80% (8/10) * One subject with circumpapillary tumor that did not meet Phase 3 criteria is not included Subtherapeutic Therapeutic High Tumor Control Rates with Therapeutic Regimen in Phase 3 Eligible Patients with Active Growth Dose Response: Subtherapeutic vs Therapeutic Regimen >90% Completed 12 Months Tumor Progression: change from baseline in thickness ≥0.5mm; or in LBD ≥1.5mm confirmed by at least one repeat assessment August 3, 2023, data on file Aura Biosciences *A local complete response, or CR, in early-stage choroidal melanoma is described as tumor control and complete arrest of tumor growth by ocular oncologists. Based on Phase 2 interim data, August 3, 2023.

High Tumor Control Rates Observed in Phase 3 Population Treated with Therapeutic Regimen in Phase 2 Progression Definition based on Tumor Thickness (Increase ≥0.5mm) Change from Baseline in Tumor Thickness Over 12 Months Treatment Timeframe Follow-up Timeframe Change from Baseline in Tumor Thickness (mm) Change from Baseline in Tumor Thickness (mm) Patients who had documented growth at entry (n=6) Patients who did not have documented growth at entry (n=4) Progression Definition based on Tumor Thickness (Increase ≥0.5mm) Change from Baseline in Tumor Thickness Over 12 Months Treatment Timeframe Follow-up Timeframe All patients with documented growth at entry (n=10) Subtherapeutic Regimens (n=10) Active Growth and 3 Cycle Regimens (n=10) Phase 2 Interim Data Demonstrated Tumor Control Rate of 80%, with 90% of Patients at 12 Months of Follow Up Based on Phase 2 interim data, August 3, 2023.

Bel-sar Therapeutic Regimen in Phase 2 Interim Data Achieved High Tumor Control Rates, with Complete Cessation of Growth Among Responders with Phase 3-eligible Tumors Tumor progression defined as change from baseline in thickness ≥0.5 mm; or in LBD ≥1.5 mm confirmed by at least one repeat assessment. aOne participant with circumpapillary tumor that did not meet phase 3 criteria is not included. bTumor thickness growth rates/slopes estimated using Mixed Models for Repeat Measures (MMRM); random intercept and slope model for Historical and Study periods.LBD, largest basal diameter. ClinicalTrials.gov Identifier, NCT04417530: AU-011-202. August 3, 2023, data on file Aura Biosciences. Participants with tumor control at 12 months, % Phase 3-eligible participantsa 80% tumor control rate at 12 monthsamong phase 3-eligible patients In phase 3-eligible tumors, the 3-cycle regimen was successful with complete cessation of growth among responders (n=8/10; P < 0.0001b) Post-treatment actual Post-treatment projected Pre-treatment actual

34 80% (8/10) of these trial participants were at high risk of vision loss with tumors < 3 mm to the fovea or optic nerve BCVA change from baseline(ETDRS letter score) Median change in BCVA in Phase 3-eligible participants with therapeutic regimen (n=10)a Study month >90% of participants completed 12 months aOne participant with circumpapillary tumor that did not meet phase 3 criteria is not included. bVision acuity loss defined as ≥15 letters decrease from baseline in ETDRS BCVA letter score. BCVA, best-corrected visual acuity; ETDRS, Early Treatment Diabetic Retinopathy Study. ClinicalTrials.gov Identifier, NCT04417530: AU-011-202. August 3, 2023, data on file Aura Biosciences. 0 6 9 12 3 3 1 −1 − 3 − 5 − 7 − 9 − 11 − 13 − 15 Vision loss thresholdb (−15 letters) Median BCVA change from baseline Visual Acuity was Preserved in 90% of Participants Receiving a Bel-sar Therapeutic Regimen Based on Phase 2 Interim Data

Phase 2 Interim Safety Data Supports Potential to be First Line Treatment in Primary Uveal Melanoma Adverse Event Radiotherapy* Bel-Sar+ Surgeries secondary to AEs+ (e.g., Cataracts) 40%+ 0% Radiation Retinopathy 40%+ 0% Neovascular Glaucoma 10% 0% Dry Eye Syndrome 20% 0% Strabismus 2%+ 0% Retinal Detachment 1-2% 0% Vision Loss (≥15 letters) ~70% ~5% Serious Adverse Event Radiotherapy* Bel-Sar+ Scleral Necrosis 0-5% 0% Enucleation/Eye Loss 10-15% 0% Severe Vision Loss (≥30 letters) in HRVL** ~90% 0%++ * Certain data in this presentation are based on a cross-trial comparisons and are not based on any head-to-head clinical trials. Cross-trial comparisons are inherently limited and may suggest misleading similarities or differences. Results of head-to-head comparisons may differ significantly from those set forth herein. +Related to bel-sar or laser **73% (16/22) of patients in Phase 2 SC trial were at high risk for vision loss Table presents percentage of subjects with AEs related to bel-sar or laser by severity and overall; subjects with more than 1 AE are counted in the highest severity group *Treatment-emergent AEs related to bel-sar or laser in 1 patient each or <5% (anisocoria, conjunctival edema, cystoid macular edema, pupillary reflex impaired, retinal pigment epitheliopathy, salivary gland enlargement) August 3, 2023, data on file Aura Biosciences Ongoing Phase 2 Safety Outcomes with SC Administration All Treated Subjects (n=22) Drug/Laser Related Adverse Events >5% Subjects* Grade I Grade II Grade III Total Anterior Chamber Inflammation 18% 0 0 18% Anterior Chamber Cell 9% 0 0 9% Eye Pain 9% 0 0 9% No Posterior Inflammation, No SAEs and No Grade 3 Related Adverse Events *J. Contemp Brachytherapy. J. 2019 Aug; 11(4): 392–397.; Arch Ophthalmol. 2000;118(9):1219-1228; Curr. Opin. Ophthalmol. 2019 May;30(3):206-214; Eye 2017 Feb;31(2):241-257**High-Risk Vision Loss (HRVL) are those subjects with tumors <3mm to fovea or optic nerve AEs – Adverse Events; SAEs – Serious Adverse Events; SC - Suprachoroidal