Exhibit 21.1

SUBSIDIARIES OF CBOE GLOBAL MARKETS, INC.

AS OF DECEMBER 31, 2022


Name of Subsidiary		Jurisdiction of Organization
Cboe Bats, LLC		Delaware
Cboe BZX Exchange, Inc.		Delaware
Cboe Clear Europe		Netherlands
Cboe Exchange, Inc.		Delaware
Cboe Services Company		Delaware
Cboe Worldwide Holdings Limited		United Kingdom
Omicron Acquisition Corp.		Delaware

The above is a list of Cboe Global Markets, Inc.’s subsidiaries as of December 31, 2022, and the states or jurisdictions in which they are organized. Pursuant to Item 601(b)(21)(ii) of Regulation S-K, excluded from the list are subsidiaries that, if considered in the aggregate, would not constitute a “significant subsidiary” as defined by Rule 1-02(w) of Regulation S-X under the Securities Exchange Act of 1934.